{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:30Z","timestamp":1786653690360,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV) has been linked as a potential risk factor for increasing incidence of oropharyngeal carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The present study aimed to evaluate the role of clinicopathologic factors in outcome prediction in subjects having oropharyngeal carcinoma associated with HPV and managed with surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The present retrospective study assessed data from 54 subjects that were diagnosed with stage III or IV HPV-associated oropharyngeal carcinoma were managed with surgery with or without adjuvant therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean follow-up duration in the study subjects was 2.7 years. The recurrence-free survival and overall survival rates [age, number of lymph nodes involved, stage of tumor, and Charleston comorbidity index] in the study subjects were 83% and 71% and 62% and 79%, respectively. The recurrence rate in the study was found to be 21%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The conclusion drawn from the present study is that some associated potential risk factors can have lesser relevance in HPV-associated oropharyngeal carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1436_24","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:05:22Z","timestamp":1735257922000},"page":"S4091-S4093","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with Surgery"],"prefix":"10.4103","volume":"16","author":[{"given":"Harsh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Dentistry, Patna Medical College, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rameet","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Luxmi Bai Institute of Dental Sciences and Hospital, Sirhind Road, Patiala, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Chhindwara Institute of Medical Sciences, Chhindwara Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanchal","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kanti Devi Dental College and Hospital, Mathura, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathi","family":"Rela","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Nalanda Medical College and Hospital, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahana","family":"Karthik","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Precious Dental Care, Fremont, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000346908","article-title":"Matched-pair analysis in patients with advanced oropharyngeal cancer:Surgery versus concurrent chemoradiotherapy","volume":"84","author":"Kano","year":"2013","journal-title":"Oncology"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2010.01.032","article-title":"Matched survival analysis in patients with locoregionally advance respectable oropharyngeal carcinoma:Platinum-based induction and concurrent chemoradiotherapy versus primary surgical resection","volume":"80","author":"Boscolo-Rizzo","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"761","DOI":"10.6004\/jnccn.2017.0101","article-title":"NCCN practice guidelines for head and neck version 2.2017","volume":"15","author":"Adelstein","year":"2017","journal-title":"J Natl Compr Canc Netw"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/hed.21669","article-title":"Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer:A united states multicenter study","volume":"33","author":"Haughey","year":"2011","journal-title":"Head Neck"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies:Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"R6-20241227","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"key":"R7-20241227","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"},{"key":"R8-20241227","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/j.ejca.2014.07.001","article-title":"De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma:A systematic review and meta-analysis of current clinical trials","volume":"50","author":"Masterson","year":"2014","journal-title":"Eur J Cancer"},{"key":"R9-20241227","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hed.24042","article-title":"Role of primary surgery in the treatment of advanced oropharyngeal cancer","volume":"38","author":"Seikaly","year":"2016","journal-title":"Head Neck"},{"key":"R10-20241227","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/lary.23493","article-title":"Prognostic factors and survival unique to surgically treated p16+oropharyngeal cancer","volume":"122","author":"Haughey","year":"2012","journal-title":"Laryngoscope"},{"key":"R11-20241227","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.oraloncology.2016.09.004","article-title":"Pathology-based staging for HPV-positive squamous carcinoma of the or pharynx","volume":"62","author":"Haughey","year":"2016","journal-title":"Oral Oncol"},{"key":"R12-20241227","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1002\/cncr.26671","article-title":"Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma","volume":"118","author":"Sinha","year":"2012","journal-title":"Cancer"},{"key":"R13-20241227","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1200\/JCO.2011.35.7301","article-title":"Population-based study of competing mortality in head and neck cancer","volume":"29","author":"Rose","year":"2011","journal-title":"J Clin Oncol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1436_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:56Z","timestamp":1786650056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1436_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":13,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1436_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-10-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}