{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:52:11Z","timestamp":1789912331677,"version":"4.0.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Background:<\/jats:title>\n Early childhood caries (ECC) is a prevalent dental condition affecting children younger than 6 years. Conventional fluoride toothpastes are effective but raise concerns regarding fluorosis and ingestion in young children. Herbal fluoride toothpastes offer a natural alternative with added antimicrobial benefits.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A randomized controlled trial was conducted among 120 children aged 3\u20135 years, divided into two groups: Group A used herbal fluoride toothpaste containing neem, clove, and 500 ppm fluoride; Group B used a nonherbal fluoride toothpaste with 500 ppm fluoride. Caries status was assessed at baseline, 6 months, and 12 months using the dmft index. Statistical analysis included paired t-tests and repeated-measures ANOVA (\n P<\/jats:italic>\n < 0.05 considered significant).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n At baseline, mean dmft scores were comparable between groups (Group A: 2.35 \u00b1 1.20; Group B: 2.42 \u00b1 1.18;\n P<\/jats:italic>\n = 0.64). After 12 months, Group A showed a significantly lower mean increase in dmft (0.42 \u00b1 0.87) compared with Group B (0.95 \u00b1 1.02;\n P<\/jats:italic>\n = 0.02). The incidence of new carious lesions was also lower in Group A (16.6%) vs. Group B (28.3%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Herbal fluoride toothpaste demonstrated greater efficacy in preventing ECC than conventional fluoride toothpaste, suggesting its potential as a safe and effective alternative in pediatric oral care.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1437_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:01:49Z","timestamp":1766044909000},"page":"S3398-S3400","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Herbal Fluoride Toothpaste in Preventing Early Childhood Caries"],"prefix":"10.4103","volume":"17","author":[{"given":"Vanisha","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Mathuradas Mathur Hospital, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akangsha","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Pacific Dental College and Research Hospital, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Orthopaedics, Government Medical College, Satna, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwesha","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Agartala Government Dental College and IGM Hospital, Agartala, Tripura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashim","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Dento Derma Multispeciality Clinic, Silchar Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhi","family":"Soni","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Pathology, Pacific Dental College and Research Hospital, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miral","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Pedodontology, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujrat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j..2003.com122.x","article-title":"The World Oral Health Report 2003: Continuous improvement of oral health in the 21st century \u2013 the approach of the WHO Global Oral Health Programme","volume":"31","author":"Petersen","year":"2003","journal-title":"Community Dent Oral 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treatment","volume":"15","author":"Bhattarai","year":"2015","journal-title":"BMC Complement Altern Med"},{"key":"R13-20251218","first-page":"114","article-title":"Anticariogenic properties of plant-based products: A review","volume":"10","author":"Yousuf","year":"2020","journal-title":"J Oral Biol Craniofac Res"},{"issue":"Suppl 2","key":"R14-20251218","first-page":"S126","article-title":"Comparative evaluation of efficacy of herbal and conventional dentifrices on plaque and gingivitis: A clinical trial","volume":"4","author":"Patil","year":"2014","journal-title":"J Int Soc Prev Community Dent"},{"key":"R15-20251218","first-page":"CD002284","article-title":"Fluoride mouthrinses for preventing dental caries in children and adolescents","volume":"7","author":"Marinho","year":"2016","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Journal of Pharmacy and Bioallied 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