{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:16Z","timestamp":1787071456030,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitamin D plays a crucial role in skeletal growth, bone mineralization, and musculoskeletal health. A rising trend in vitamin D deficiency among children has raised concerns, particularly with complaints of chronic musculoskeletal pain that may be attributable to suboptimal vitamin D levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A cross-sectional observational study was conducted over 12 months in a tertiary pediatric hospital. A total of 300 children presenting with nonspecific musculoskeletal pain were enrolled. Serum 25-hydroxyvitamin D [25(OH) D] levels were measured, and musculoskeletal pain was assessed using a Visual Analog Scale (VAS) and physical examination. Children were categorized into vitamin D sufficient (&gt;30 ng\/mL), insufficient (20-30 ng\/mL), and deficient (&lt;20 ng\/mL) groups. Statistical analysis included ANOVA and chi-square tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 300 children, 180 (60%) were vitamin D deficient, 72 (24%) insufficient, and 48 (16%) sufficient. Mean serum 25(OH) D levels were 16.2 \u00b1 4.3 ng\/mL in the deficient group and 31.7 \u00b1 3.5 ng\/mL in the sufficient group. Children with deficiency reported higher VAS scores (mean: 6.8 \u00b1 1.5) compared to those with sufficient levels (mean: 3.1 \u00b1 1.1,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Lower limb pain (56%) and generalized body aches (43%) were more frequent in the deficient group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vitamin D deficiency is significantly associated with increased severity and widespread distribution of musculoskeletal pain in children. Early screening and supplementation may reduce symptom burden and improve quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1438_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:01:11Z","timestamp":1766044871000},"page":"S3025-S3027","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Vitamin D Deficiency and its Association with Musculoskeletal Pain in Children"],"prefix":"10.4103","volume":"17","author":[{"given":"Amreen","family":"Aijazuddin","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Kings Dental Centre, Al Markhiya, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh Chandra","family":"Patidar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Zulekha Hospital, Sharjah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apna","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, SGT University, Gurgaon, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. N.","family":"Tharunkumar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Sunny Babu","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miral","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1542\/peds.2007-1894","article-title":"Vitamin D deficiency in children and its management: 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Metab"},{"key":"R9-20251218","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3109\/02813432.2010.505407","article-title":"Vitamin D status in patients with musculoskeletal pain, fatigue and headache: A cross-sectional descriptive study in a multi-ethnic general practice in Norway","volume":"28","author":"Knutsen","year":"2010","journal-title":"Scand J Prim Health Care"},{"key":"R10-20251218","first-page":"1215","article-title":"Vitamin D deficiency and musculoskeletal pain in children: A review","volume":"65","author":"Riaz","year":"2011","journal-title":"Eur J Clin Nutr"},{"key":"R11-20251218","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1043-2760(01)00547-1","article-title":"New clues about vitamin D functions in the nervous system","volume":"13","author":"Garcion","year":"2002","journal-title":"Trends Endocrinol Metab"},{"key":"R12-20251218","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1503\/cmaj.061377","article-title":"Vitamin 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