{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:20:48Z","timestamp":1790565648832,"version":"4.1.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Periodontitis, a widespread chronic inflammatory disease, is primarily treated with scaling and root planing (SRP). However, plant-based adjunctive therapies, known for their anti-inflammatory, antimicrobial, and antioxidant effects, are emerging as valuable complements to SRP. This review presents findings from 24 studies on agents such as Edelweiss stem cells, pomegranate, neem, chamomile, and curcumin, which showed enhanced clinical outcomes in probing pocket depth (PPD) and clinical attachment levels (CAL) when used with SRP. These therapies offer safe and biocompatible alternatives to synthetic agents, potentially reducing antibiotic dependence and addressing antimicrobial resistance. The localized application of these agents maximizes periodontal benefits with minimal systemic exposure.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1441_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:09Z","timestamp":1766044809000},"page":"S2867-S2869","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of Plant-Based and Herbal Therapies in Periodontal Treatment: Clinical Applications, Mechanistic Insights, and Efficacy"],"prefix":"10.4103","volume":"17","author":[{"given":"Hiroj","family":"Bagde","sequence":"first","affiliation":[{"name":"PhD Scholar, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallapragada","family":"Siddharth","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Dhopte","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Chhattisgarh Dental College and Research institute, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Public health Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahavir University, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Khursheed","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Preventive dentistry, College of Dentistry, Al Jouf University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Autonomous State Medical College, Pilibhit, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4103\/ccd.ccd_183_22","article-title":"Clinical and radiographic evaluation of locally delivered plant stem cells for treatment of periodontitis: Randomized clinical trial","volume":"14","author":"Elboraey","year":"2023","journal-title":"Contemp Clin Dent"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/jisp.jisp_243_20","article-title":"A comparison of the efficacy of scaling and root planning with application of pomegranate chip, pomegranate gel, and scaling and root planing in sufferers with adult periodontitis-A prospective study","volume":"25","author":"Tyagi","year":"2021","journal-title":"J Indian Soc 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