{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:56Z","timestamp":1787071496873,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      To assess the link between ACLs and salivary parameters (\n                      <jats:italic toggle=\"yes\">CA VI<\/jats:italic>\n                      , pH, buffering capacity, \u03b1-amylase, and SFR) in adolescents (12\u201317 years) with fixed orthodontic appliances.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>\n                      A longitudinal observational study with 100 healthy adolescents. Stimulated saliva samples were collected at baseline, 1, 3, 6, and 12 months post-application. Parameters measured included SFR, pH, buffering capacity, \u03b1-amylase, and\n                      <jats:italic toggle=\"yes\">CA VI<\/jats:italic>\n                      . ACLs were diagnosed using Nyvad\u2019s criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      SFR increased at one month in non-ACL patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2248 0.0283) and correlated with\n                      <jats:italic toggle=\"yes\">CA VI<\/jats:italic>\n                      at three months. Buffering capacity dropped at three months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) and partially recovered by 12 months. \u03b1-Amylase decreased at one and six months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0003).\n                      <jats:italic toggle=\"yes\">CA VI<\/jats:italic>\n                      positively correlated with SFR at three months and negatively with pH at one month. New caries appeared around three months, aligning with reduced enzymatic and buffering defenses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Orthodontic treatment triggers early salivary flow increases, but declines in buffering capacity, \u03b1-amylase, and\n                      <jats:italic toggle=\"yes\">CA VI<\/jats:italic>\n                      between three and six months coincide with ACL onset. This high-risk phase highlights the need for early preventive care, despite parameter recovery by 12 months.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1443_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:02:59Z","timestamp":1766044979000},"page":"S3401-S3403","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Salivary Parameters in Teenagers Undergoing Orthodontic Treatment in Caries Development"],"prefix":"10.4103","volume":"17","author":[{"given":"Vijender","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Orthodontics, MM College of Dental Sciences and Research, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashim","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Dento Derma Multispeciality Clinic, Silchar, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apna","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, SGT University, Gurgaon, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ubaid","family":"Kureshi","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, KM Shah Dental College and Hospital, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujrat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanket","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopaedics, K. M. Shah Dental College and Hospital, Sumandeep University (deemed to be), Vadodara, Gujrat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshni","family":"Mahajan","sequence":"additional","affiliation":[{"name":"BDS Intern, Government Dental College, Patiala, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Beverly Hills Medical Center, Abu Dhabi, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","first-page":"52","article-title":"Association between orthodontic treatment and dental caries in adolescents: A cross-sectional study","volume":"18","author":"Cardoso","year":"2017","journal-title":"Eur J Paediatr Dent"},{"key":"R2-20251218","first-page":"5","article-title":"Effect of self-ligating brackets on oral hygiene and microbiologic parameters in orthodontic patients","volume":"14","author":"Bonetti","year":"2013","journal-title":"Prog Orthod"},{"key":"R3-20251218","first-page":"e15193","article-title":"Changes in oral microbiome during orthodontic treatment: A longitudinal study","volume":"11","author":"Jakavi\u010d\u0117","year":"2023","journal-title":"PeerJ"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1159\/000470849","article-title":"Association between dental biofilm and caries lesion activity in children","volume":"51","author":"Picco","year":"2017","journal-title":"Caries Res"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000337275","article-title":"Adhesive performance of self-etch systems after selective enamel etching","volume":"46","author":"Frasseto","year":"2012","journal-title":"Caries Res"},{"key":"R6-20251218","first-page":"17914","article-title":"The microbiome of saliva in relation to dental caries development","volume":"9","author":"Esberg","year":"2019","journal-title":"Sci Rep"},{"key":"R7-20251218","first-page":"64","article-title":"Effect of orthodontic treatment on clinical and microbiological parameters of periodontal health: A longitudinal study","volume":"17","author":"Teixeira","year":"2012","journal-title":"Dent Press J Orthod"},{"key":"R8-20251218","first-page":"358","article-title":"Oral microbiome changes during orthodontic treatment: A prospective study","volume":"9","author":"Al Mahdi","year":"2023","journal-title":"Clin Exp Dent Res"},{"key":"R9-20251218","first-page":"e10","article-title":"Oral hygiene practices and caries experience among schoolchildren: A community-based study","volume":"50","author":"Vasudevan","year":"2022","journal-title":"Community Dent Oral Epidemiol"},{"key":"R10-20251218","doi-asserted-by":"crossref","first-page":"e17429","DOI":"10.7717\/peerj.17429","article-title":"Effects of fixed orthodontic appliances on salivary parameters and oral microbiota composition","volume":"12","author":"Souza","year":"2024","journal-title":"Peer J"},{"key":"R11-20251218","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/ipd.12249","article-title":"Relationship between early childhood caries and feeding practices: A longitudinal cohort study","volume":"27","author":"Borghi","year":"2016","journal-title":"Int J Paediatr Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1443_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:00Z","timestamp":1787068020000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1443_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":11,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1443_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-08-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}