{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:57:54Z","timestamp":1787183874367,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Background:<\/jats:title>\n \n Denture wearers are susceptible to fungal infections due to plaque accumulation on the tissue surface of dentures. The porosity and roughness of poly methyl methacrylate (PMMA) denture base resin provide an ideal niche for\n Candida albicans<\/jats:italic>\n colonization, which can lead to denture stomatitis.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This\n in vitro<\/jats:italic>\n study included 60 PMMA specimens\u201430 circular discs (20 mm \u00d7 2 mm) for antifungal testing and 30 rectangular bars (65 mm \u00d7 10 mm \u00d7 2.5 mm) for flexural strength testing. Three groups (n = 10 each) were prepared for both shapes: Group A (control), Group B (0.5% silver nanoparticles (AgNP)), and Group C (1% AgNP). Antifungal activity was assessed using the lawn culture method with the ATCC 28366 strain of\n C. albicans<\/jats:italic>\n , recording zones of inhibition. Flexural strength was measured using a universal testing machine with three-point loading.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n For antifungal activity, Group B (0.5% AgNP) showed the largest mean inhibition zone (20.20 \u00b1 1.31 mm), followed by Group C (1% AgNP) (15.90 \u00b1 0.87 mm), while the control group showed no inhibition. Differences among all groups were statistically significant (\n P<\/jats:italic>\n = 0.001). Flexural strength was highest in the control group (91.06 \u00b1 6.48 MPa), followed by Group B (76.09 \u00b1 14.04 MPa) and Group C (57.92 \u00b1 4.20 MPa). All intergroup differences were statistically significant (\n P<\/jats:italic>\n < 0.005).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Incorporating AgNP into PMMA denture base resin significantly enhances antifungal activity against\n C. albicans<\/jats:italic>\n , with 0.5% AgNP showing superior inhibition compared to 1%.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1444_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:49Z","timestamp":1766044849000},"page":"S3382-S3384","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["An in vitro Comparison and Evaluation of Silver Nanoparticles Incorporated Poly Methyl Methacrylate Acrylic Denture Resin Against Candida albicans"],"prefix":"10.4103","volume":"17","author":[{"given":"Nitesh","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Chhatttisgarh Dental College and Research Institute, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil P.","family":"Melitt","sequence":"additional","affiliation":[{"name":"Restorative Dentist, MyDentist Clinic, Ludlow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Jassim","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Crown and Bridge, Sree Anjaneya Institute of Dental Sciences, Modakkallur, Calicut, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Thomas","family":"Philip","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Crown and Bridge, Sree Anjaneya Institute of Dental Sciences, Modakkallur, Calicut, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Dhopte","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tripleo.2003.04.002","article-title":"Denture stomatitis: A role for Candida biofilms","volume":"98","author":"Ramage","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R2-20251218","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1532-849X.2011.00698.x","article-title":"Epidemiology and etiology of denture stomatitis","volume":"20","author":"Gendreau","year":"2011","journal-title":"J Prosthodont"},{"key":"R3-20251218","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1034\/j.1600-0722.2001.00089.x","article-title":"Effect of removable orthodontic appliances on oral colonization by mutans streptococci in children","volume":"109","author":"Batoni","year":"2001","journal-title":"Eur J Oral Sci"},{"key":"R4-20251218","first-page":"113","article-title":"The association of denture stomatitis and partial removable dental prostheses: A systematic review","volume":"25","author":"Emami","year":"2012","journal-title":"Int J Prosthodont"},{"key":"R5-20251218","doi-asserted-by":"crossref","first-page":"454090","DOI":"10.4061\/2011\/454090","article-title":"Biosynthesis of silver nanoparticles from Desmodium triflorum: A novel approach towards weed utilization","volume":"2011","author":"Ahmad","year":"2011","journal-title":"Biotechnol Res Int"},{"key":"R6-20251218","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1007\/s10853-005-4339-8","article-title":"The effect of filler particle size on the antibacterial properties of compounded polymer\/silver fibers","volume":"40","author":"Jeong","year":"2005","journal-title":"J Mater Sci"},{"key":"R7-20251218","first-page":"5556413","article-title":"Antifungal activity of denture base resin containing nanozirconia: In vitro assessment of candida albicans biofilm","author":"Abualsaud","year":"2021","journal-title":"Sci World J"},{"key":"R8-20251218","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1741-2358.2007.00198.x","article-title":"Antimicrobial and mechanical properties of acrylic resins with incorporated silver-zinc zeolite \u2013 Part I","volume":"25","author":"Casemiro","year":"2008","journal-title":"Gerodontology"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1444_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:31Z","timestamp":1787067991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1444_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":8,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1444_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-08-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}