{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:48Z","timestamp":1787775828877,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Chronic periodontitis is a prevalent inflammatory disease characterized by the progressive destruction of the tooth-supporting apparatus. This randomized controlled clinical trial investigated the comparative efficacy of two such adjuncts: bioactive glass microspheres, known for their regenerative potential, and chlorhexidine chips, renowned for their antimicrobial properties.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Participants with moderate-to-severe chronic periodontitis were randomly allocated to three groups: Group 1 received SRP plus bioactive glass microspheres, Group 2 received SRP plus chlorhexidine chips, and Group 3 underwent SRP alone (control). Clinical parameters, including probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP), were meticulously recorded at baseline, 3 months, and 6 months post-intervention.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n All three groups exhibited statistically significant improvements in all clinical parameters from baseline to the 6-month follow-up. However, the groups receiving adjunctive therapies demonstrated superior outcomes compared to SRP alone. Intergroup comparisons revealed statistically significant differences between the bioactive glass group and the control group (\n P<\/jats:italic>\n < 0.01) and between the chlorhexidine group and the control group (\n P<\/jats:italic>\n < 0.05) for all parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Both bioactive glass microspheres and chlorhexidine chips, when used as adjuncts to SRP, offer significant clinical advantages in the treatment of chronic periodontitis compared to SRP alone. The superior performance of bioactive glass microspheres suggests their potential as a preferred adjunctive therapy, possibly attributed to their combined regenerative and antimicrobial properties.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_146_25","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:00:26Z","timestamp":1746849626000},"page":"S577-S579","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Evaluation of Bioactive Glass Microspheres versus Chlorhexidine Chips in the Treatment of Chronic Periodontitis: A Randomized Controlled Clinical Trial"],"prefix":"10.4103","volume":"17","author":[{"given":"Anuj Singh","family":"Parihar","sequence":"first","affiliation":[{"name":"Department of Periodontology, People\u2019s Dental Academy, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay T.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Karnavati School of Dentistry, Karnavati University, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiren H.","family":"Patadiya","sequence":"additional","affiliation":[{"name":"My Dental Southbridge 305, Main Street Southbridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sadananda","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Government Dental College and Research Institute, BMCRC, Ballari, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Adatrow","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Karnavati School of Dentistry, Karnavati University, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Laddha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dr. RR Kambe Dental College and Hospital, Akola, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Karnavati School of Dentistry Karnavati University Gandhinagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990-2010:A systematic review and meta-regression","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J Dent Res"},{"issue":"(Suppl 20)","key":"R2-20250513","first-page":"S149","article-title":"Staging and grading of periodontitis:Framework and proposal of a new classification and case definition","volume":"45","author":"Tonetti","year":"2018","journal-title":"J Clin Periodontol"},{"key":"R3-20250513","first-page":"975","article-title":"Bioactive glass granules enhance periodontal regeneration compared to open flap debridement alone:A randomized controlled trial","volume":"44","author":"Schepers","year":"2017","journal-title":"J Clin Periodontol"},{"key":"R4-20250513","first-page":"10","article-title":"Local antimicrobial therapy in periodontal diseases:A systematic review","volume":"49","author":"Montes","year":"2022","journal-title":"J Clin Periodontol"},{"key":"R5-20250513","first-page":"493","article-title":"Bioactive glass in the treatment of periodontal bony defects:A systematic review","volume":"38","author":"Jepsen","year":"2011","journal-title":"J Clin Periodontol"},{"key":"R6-20250513","first-page":"237","article-title":"Local delivery of chlorhexidine in the treatment of periodontitis:A systematic review and meta-analysis","volume":"44","author":"Van der Weijden","year":"2017","journal-title":"J Clin Periodontol"},{"key":"R7-20250513","first-page":"4357","article-title":"Bioactive glass in periodontal and peri-implant regeneration:Current evidence and future perspectives","volume":"13","author":"Giannopoulou","year":"2020","journal-title":"Materials"},{"key":"R8-20250513","first-page":"363","article-title":"Clinical and radiographic evaluation of a novel bioactive glass in the treatment of intrabony defects:A randomized controlled trial","volume":"25","author":"Aimetti","year":"2021","journal-title":"Clin Oral Investig"},{"key":"R9-20250513","first-page":"119","article-title":"Osseointegration of titanium implants with a bioactive glass coating:A histologic study in dogs","volume":"37","author":"Bosshardt","year":"2022","journal-title":"Int J Oral Maxillofac Implants"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_146_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:38Z","timestamp":1787773418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_146_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":9,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_146_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-01-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}