{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:25:22Z","timestamp":1787772322757,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Neuroprotectants are drugs or substances that help protect the brain and nerves from damage caused by injuries or diseases like stroke, Alzheimer\u2019s disease, and Parkinson\u2019s disease. This review looks at different types of neuroprotective agents, including those that reduce inflammation, prevent cell death, or improve blood flow to the brain. While many of these substances show good results in lab studies, only a few have been successful in human trials. This is often due to problems like delayed treatment, difficulty reaching the brain, and differences between patients. The review also discusses future clinical trials and how new technologies and targeted treatments may improve outcomes. Understanding how these agents work and how to test them better could lead to more effective treatments for brain disorders.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1472_25","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T14:01:13Z","timestamp":1768226473000},"page":"S1-S3","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Neuroprotectants: The Next Frontier in Neurology"],"prefix":"10.4103","volume":"18","author":[{"given":"Patel","family":"Khushi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Surat Medical Institute of Medicine and Research (SMIMER), Surat, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha Jayantilal","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. N D Desai Faculty of Medical Science and Research, Dharmsinh Desai University, Nadiad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Daga","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, SMRCH, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Sethumadhavan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Crown and Bridge, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi Kamlesh","family":"Kale","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Crown and Bridge, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Laddha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, DR Rajesh Ramdasji Kambe Dental College and Hospital, Akola, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12975-010-0024-6","article-title":"Beyond neuroprotection to brain repair: exploring the next frontier in clinical neuroscience to expand the therapeutic window for stroke","volume":"1","author":"Ratan","year":"2010","journal-title":"Transl Stroke Res"},{"key":"R2-20260310","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1017\/cjn.2021.223","article-title":"Neuroprotection in acute ischemic stroke: A brief review","volume":"49","author":"Buchan","year":"2022","journal-title":"Can J Neurol Sci"},{"key":"R3-20260310","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1570159X17666190726104139","article-title":"Pharmacological interventions and rehabilitation approach for enhancing brain self-repair and stroke recovery","volume":"18","author":"Szelenberger","year":"2020","journal-title":"Curr Neuropharmacol"},{"key":"R4-20260310","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroscience.2018.09.006","article-title":"A salidroside analog confers neuroprotection with a wide therapeutic window by regulating local glucose metabolism in a rat model of cerebral ischemic injury","volume":"391","author":"Yu","year":"2018","journal-title":"Neuroscience"},{"key":"R5-20260310","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000015817","article-title":"Neuroprotection as initial therapy in acute stroke. 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