{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:34Z","timestamp":1787840614471,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Gestational diabetes mellitus (GDM) is associated with adverse maternal and neonatal outcomes and an increasing global prevalence. Preventive interventions during pregnancy may help mitigate these risks. This systematic review and meta-analysis evaluated randomized controlled trials assessing lifestyle, exercise, and pharmacologic interventions for the prevention of GDM. Comprehensive searches were conducted in PubMed, Scopus, Web of Science, Cochrane CENTRAL, and Google Scholar up to May 2025. The primary outcome was GDM incidence, and secondary outcomes included fasting glucose, gestational weight gain, maternal and neonatal outcomes, adherence, and safety. Nine randomized controlled trials were identified, of which seven involving 4,046 women were included in the meta-analysis. Pooled analysis showed that antenatal interventions significantly reduced GDM incidence (odds ratio [OR] 0.55, 95% confidence interval [CI] 0.41\u20130.75). Lifestyle programs (OR 0.56, 95% CI 0.39\u20130.80) and exercise-only interventions (OR 0.63, 95% CI 0.40\u20131.00) were most effective. Improvements in fasting glucose, gestational weight gain, cesarean delivery, and macrosomia were observed without increased adverse events. Structured lifestyle and exercise interventions are effective, safe, and scalable strategies for preventing GDM.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1488_25","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:01:39Z","timestamp":1761753699000},"page":"117-121","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Preventing Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Lifestyle, Exercise, and Pharmacologic Interventions"],"prefix":"10.4103","volume":"17","author":[{"given":"Supraja","family":"Movva","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Mid Yorkshire NHS Trust, Wakefield, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya Kumar","family":"Koduru","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, Northern Lincolnshire and Goole NHS Foundation Trust (NLAG), Scunthorpe, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthi","family":"Roop","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, Northern Lincolnshire and Goole NHS Foundation Trust (NLAG), Scunthorpe, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Pandiyarajan","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, Northern Lincolnshire and Goole NHS Foundation Trust (NLAG), Scunthorpe, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, Northern Lincolnshire and Goole NHS Foundation Trust (NLAG), Scunthorpe, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbind Kumar","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Government Erode Medical College and Hospital, Erode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/AOG.0b013e3182393f86","article-title":"Regular exercise during pregnancy to prevent gestational diabetes: A randomized controlled trial","volume":"119","author":"Stafne","year":"2012","journal-title":"Obstet Gynecol"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1249\/MSS.0000000000000547","article-title":"Exercise is associated with a reduction in gestational diabetes mellitus","volume":"47","author":"Cordero","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2337\/dc15-0511","article-title":"Gestational diabetes mellitus can be prevented by lifestyle intervention: the RADIEL Study","volume":"39","author":"Koivusalo","year":"2016","journal-title":"Diabetes Care"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1136\/bjsports-2015-094756","article-title":"Exercise during pregnancy. 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