{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:59:04Z","timestamp":1791284344652,"version":"4.1.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Recurrent apthous stomatitis (RAS) and recurrent apthous ulcers are common oral ulcers which are associated with a significant amount of pain and reduction in quality of life, where traditional mainstay of treatment is topical steroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A case control study was undertaken on 90 patients seeking treatment for minor RAS and was divided into three groups. An index ulcer was selected and treated with 0.1% tacrolimus, 0.1% triamcinolone acetonide, and placebo, respectively, for 1 week.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At the end of day 2, the mean percentage reduction was 44.16%, 79.82% at day 5 and 94.26% at day 7 in the tacrolimus group, which was comparatively higher than the other two groups at day 2, day 5, and day 7. Recurrence was reported in all three groups but was not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results of the study suggest that 0.1% tacrolimus is more effective as an immediate mode of treatment than 0.1% triamcinolone acetonide or placebo in the management of recurrent aphthous ulcers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1498_24","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:10:21Z","timestamp":1735258221000},"page":"S4107-S4110","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Evaluation of Tacrolimus 0.1% in Orabase and Triamcinolone Acetonide 0.1% in the Management of Recurrent Apthous Stomatitis (RAS) \u2013 A Case Control Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Deepthi Chandrika","family":"Manukonda","sequence":"first","affiliation":[{"name":"M.S.N. Multispeciality Dental Clinic, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan Kumar","family":"Yellarthi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh Kumar","family":"Pakki","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N V V Satya","family":"Bhushan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. V.","family":"Radha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Ramani","family":"Chintada","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"R1-20241227","first-page":"74","article-title":"Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners","volume":"7","author":"Tarakji","year":"2015","journal-title":"J Int Oral Heal"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tripleo.2009.11.006","article-title":"Evaluation of penicillin G potassium troches in the 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trial","volume":"55","author":"Wang","year":"2015","journal-title":"J Clin Pharmacol"},{"key":"R9-20241227","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cden.2013.12.002","article-title":"Recurrent aphthous stomatitis","volume":"58","author":"Akintoye","year":"2014","journal-title":"Dent Clin North Am"},{"key":"R10-20241227","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.oooo.2014.05.018","article-title":"Treatment of a Crohn's disease-related cutaneous facial lesion with topical tacrolimus","volume":"118","author":"Shah","year":"2014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"R11-20241227","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4103\/0970-9290.123382","article-title":"A clinical evaluation of 5% amlexanox oral paste in the treatment of minor recurrent aphthous ulcers and comparison with the placebo paste:A randomized, vehicle controlled, parallel, single center clinical trial","volume":"24","author":"Bhat","year":"2013","journal-title":"Indian J Dent Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1498_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:52Z","timestamp":1786650052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1498_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":11,"journal-issue":{"issue":"Suppl 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