{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:25:55Z","timestamp":1787761555423,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"\n Background:<\/jats:title>\n To evaluate and compare salivary osteocalcin concentrations in individuals with dental implants, stratified according to smoking status.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n In total, 100 participants were recruited, comprising 50 smokers and 50 non-smokers. All the patients underwent dental implant therapy. Collection of salivary samples was done and analyzed for osteocalcin levels. The data obtained were systematically tabulated, and statistical analysis was performed using SPSS software.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Group I (non-smokers) consisted of 50 individuals, while Group II (smokers) also comprised 50 individuals. The mean salivary osteocalcin concentration was 2.58 ng\/mL in the non-smoker group and 1.69 ng\/mL in the smoker group, indicating a substantial reduction among smokers.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Patients rehabilitated with dental implants who reported tobacco use exhibited diminished salivary osteocalcin concentrations when compared with their non-smoking counterparts, suggesting an adverse influence of smoking on peri-implant bone metabolic activity.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1511_25","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:00:17Z","timestamp":1771063217000},"page":"S75-S77","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Salivary Osteocalcin Level Among Smokers and Non-Smokers Undergoing Dental Implants: An Observational Study"],"prefix":"10.4103","volume":"18","author":[{"given":"Sipra","family":"Sarin","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Dasmesh Institute of Research and Dental Sciences, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Dasmesh Institute of Research and Dental Sciences, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Kodagu Institute of Medical Sciences, Kodagu, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartiki","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Desh Bhagat Dental College, Mandi Gobindgarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreanshi","family":"Jolly","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Grover Dental World and Facial Aesthetic Studio, Panchkula, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Abhidi","sequence":"additional","affiliation":[{"name":"Grover Dental World and Facial Aesthetic Studio, Panchkula, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1902\/annals.1996.1.1.821","article-title":"Periodontal diseases: Pathogenesis","volume":"1","author":"Offenbacher","year":"1996","journal-title":"Ann Periodontol"},{"key":"R2-20260310","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s41598-020-58585-4","article-title":"Analysis of endothelin-1 concentrations in individuals with periodontitis","volume":"10","author":"Isola","year":"2020","journal-title":"Sci Rep"},{"key":"R3-20260310","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.3390\/nu11122956","article-title":"Assessment of vitamin C and antioxidant profiles in saliva and serum in patients with periodontitis and ischemic heart disease","volume":"11","author":"Isola","year":"2019","journal-title":"Nutrients"},{"key":"R4-20260310","first-page":"174","article-title":"Periodontitis and bone metabolism. 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Cases Miner","volume":"12","author":"Barbato","year":"2015","journal-title":"Bone Metab"},{"key":"R5-20260310","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S8756-3282(01)00480-X","article-title":"Bone marker nomenclature","volume":"28","author":"Delmas","year":"2001","journal-title":"Bone"},{"key":"R6-20260310","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fcell.2017.00103","article-title":"Potential use of human periapical cyst-mesenchymal stem cells (hPCy-MSCs) as a novel stem cell source for regenerative medicine applications","volume":"5","author":"Tatullo","year":"2017","journal-title":"Front Cell Dev Biol"},{"key":"R7-20260310","first-page":"3","article-title":"Nature of plaque","volume":"9","author":"Bowen","year":"1976","journal-title":"Oral Sci Rev"},{"key":"R9-20260310","doi-asserted-by":"crossref","first-page":"322","DOI":"10.14219\/jada.archive.2006.0181","article-title":"Salivary biomarkers of existing periodontal disease: A cross-sectional study","volume":"137","author":"Miller","year":"2006","journal-title":"J Am Dent Ass"},{"key":"R10-20260310","first-page":"53","article-title":"Smoking and periodontal disease-A review","volume":"14","author":"Pej\u010di\u0107","year":"2007","journal-title":"Med Biol"},{"key":"R11-20260310","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.archoralbio.2003.11.004","article-title":"Salivary calcium reflects skeletal bone density of heavy smokers","volume":"49","author":"Sew\u00f3n","year":"2004","journal-title":"Arch Oral Biol"},{"key":"R12-20260310","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1601-0825.2010.01721.x","article-title":"Salivary osteocalcin levels are decreased in smoker chronic periodontitis patients","volume":"17","author":"Oz\u00e7aka","year":"2011","journal-title":"Oral Dis"},{"key":"R13-20260310","first-page":"237","article-title":"Evaluation of salivary osteocalcin level in smokers and non-smokers with dental implants: research article","volume":"14","author":"Fakhrzadeh","year":"2022","journal-title":"Journal of Osseointegration,"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1511_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:01:42Z","timestamp":1787760102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1511_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":12,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1511_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-08-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}