{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:32:58Z","timestamp":1787070778832,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Medication-related osteonecrosis of the jaw (MRONJ) is a serious and debilitating condition characterized by exposed bone in the maxillofacial region in patients with a history of antiresorptive or antiangiogenic therapy. While various management strategies exist, there is no universally accepted standard of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective chart review was conducted for 30 patients diagnosed with MRONJ, who were treated at our institution between 2024 and 2025. All patients received a standardized protocol consisting of a medical regimen (pre- and post-operative antibiotics, chlorhexidine mouthwash, and a drug holiday) followed by surgical intervention (sequestrectomy or debridement with primary wound closure).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The primary outcome, complete resolution, was achieved in 83.3% of patients, with a recurrence rate of 16.7%. The mean healing time was approximately 10.4 weeks. Post-operative complications were infrequent but did occur, including wound dehiscence (13.3%), postoperative infection (10%), and pain (26.7%). These results suggest that the combined medical and surgical protocol is a highly effective treatment for MRONJ, yielding a favorable resolution rate with manageable complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The combined medical and surgical protocol is a highly effective and reliable treatment strategy for MRONJ. The high rate of complete resolution and low rate of complications support this approach as a viable management option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1532_25","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:00:07Z","timestamp":1767679207000},"page":"S239-S241","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy of a Combined Medical and Surgical Protocol in the Management of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study"],"prefix":"10.4103","volume":"18","author":[{"given":"Devang R.","family":"Deshpande","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Surgery, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harika","family":"Gadde","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi A.","family":"Gonuguntla","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devisri P.","family":"Peram","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshi V Ram","family":"Dhara","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samreen I.","family":"Shaik","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"92","DOI":"10.15171\/jlms.2018.19","article-title":"Combined approach to treat medication-related osteonecrosis of the jaws","volume":"9","author":"Merigo","year":"2018","journal-title":"J Lasers Med Sci"},{"key":"R2-20260310","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.coms.2015.06.007","article-title":"Management of medication-related osteonecrosis of the jaw","volume":"27","author":"Williams","year":"2015","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"R3-20260310","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joms.2003.08.023","article-title":"Efficacy of platelet-rich plasma in alveolar bone grafting","volume":"62","author":"Oyama","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"R4-20260310","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.5037\/jomr.2023.14401","article-title":"Comparison of the effectiveness of conservative and surgical treatment of medication-related osteonecrosis of the jaw: A systematic review","volume":"14","author":"Seluki","year":"2023","journal-title":"J Oral Maxillofac Res"},{"key":"R5-20260310","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.surge.2011.09.002","article-title":"Bisphosphonate osteonecrosis of the jaw: A historical and contemporary review","volume":"10","author":"McLeod","year":"2012","journal-title":"Surgeon"},{"key":"R6-20260310","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ijom.2020.07.036","article-title":"Enhancement of bone perfusion through cortical perforations to improve healing of medication-related osteonecrosis of the jaw: A retrospective study","volume":"50","author":"Guo","year":"2021","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R7-20260310","first-page":"99","article-title":"Oral surgical management of bone and soft tissues in MRONJ treatment: A decisional tree","volume":"10","author":"Marcian\u00f2","year":"2020","journal-title":"Life (Basel)"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1532_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:36:26Z","timestamp":1787067386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1532_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":7,"journal-issue":{"issue":"Suppl 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