{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:33Z","timestamp":1787840433033,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Restoring the structure and functionality of periodontal tissues is the goal of the intricate biological process known as periodontal regeneration. Autologous blood products like platelet-rich fibrin (PRF) have drawn interest because of their capacity to hasten healing and encourage tissue regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Procedures:<\/jats:title>\n                    <jats:p>\n                      This randomized clinical study included 30 patients with chronic periodontitis who needed regenerative periodontal treatment. Patients were split into two groups: 15 patients in the test group got PRF together with bone transplant, while 15 patients in the control group received bone graft alone. At baseline, 3 months, and 6 months after surgery, clinical measures such as radiographic bone fill, clinical attachment level (CAL), and probing depth (PD) were measured. Analysis of variance and paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests were used for statistical analysis of the data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings:<\/jats:title>\n                    <jats:p>\n                      When compared to the control group, the test group\u2019s clinical results after 6 months were noticeably better. The test group\u2019s mean PD decrease was 4.2 \u00b1 0.8 mm, whereas the control group\u2019s was 3.0 \u00b1 0.6 mm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The test group\u2019s CAL increase was 3.5 \u00b1 0.7 mm, whereas the control group\u2019s was 2.6 \u00b1 0.5 mm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). According to the radiographic study, the test group had a higher percentage of bone fill (68%) than the control group (45%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>When compared to standard therapy alone, the inclusion of PRF dramatically improved periodontal regeneration in terms of CAL gain, bone fill, and PD reduction. PRF deserves further research in bigger clinical trials since it is a potential adjuvant in regenerative periodontal treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_155_25","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:01:40Z","timestamp":1750208500000},"page":"S1285-S1287","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Platelet-Rich Fibrin (PRF) in Enhancing Periodontal Regeneration"],"prefix":"10.4103","volume":"17","author":[{"given":"Fatema","family":"Akhter","sequence":"first","affiliation":[{"name":"Department of Surgical and Diagnostic Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","first-page":"327","article-title":"Slow release of growth factors and enhanced angiogenesis with PRF","volume":"36","author":"Dohan","year":"2010","journal-title":"J Oral Implantol"},{"key":"R2-20250618","first-page":"155","article-title":"PRF: An opportunity in regenerative dentistry","volume":"10","author":"Choukroun","year":"2006","journal-title":"Clin Oral Investig"},{"key":"R3-20250618","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00784-017-2133-z","article-title":"Use of platelet-rich fibrin in regenerative dentistry: A systematic review","volume":"21","author":"Miron","year":"2017","journal-title":"Clin Oral Investig"},{"key":"R4-20250618","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.4103\/JPBS.JPBS_41_19","article-title":"Platelet-Rich Plasma and Platelet-Rich Fibrin in Periodontal Regeneration: A Review","volume":"11","author":"Mohan","year":"2019","journal-title":"J Pharm Bioallied Sci"},{"key":"R5-20250618","first-page":"925","article-title":"Clinical efficacy of PRF in the treatment of intrabony defects: A randomized controlled clinical trial","volume":"38","author":"Sharma","year":"2011","journal-title":"J Clin Periodontol"},{"key":"R6-20250618","doi-asserted-by":"crossref","first-page":"159","DOI":"10.12998\/wjcc.v5.i5.159","article-title":"Evolution, current status and advances in application of platelet concentrate in periodontics and implantology","volume":"5","author":"Agrawal","year":"2017","journal-title":"World J Clin Cases"},{"key":"R7-20250618","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.2174\/138920112800624472","article-title":"Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery","volume":"13","author":"Simonpieri","year":"2012","journal-title":"Curr Pharm Biotechnol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_155_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:41Z","timestamp":1787836961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_155_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":7,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_155_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}