{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:42:49Z","timestamp":1786725769650,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This randomized controlled clinical trial compared the radiographic periapical healing outcomes of single-visit versus multiple-visit root canal treatments for teeth with apical periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Thirty patients with single-rooted teeth diagnosed with primary apical periodontitis were randomly allocated to either a single-visit (n = 15) or a multiple-visit (n = 15) group. Periapical healing was radiographically evaluated using the Periapical Index (PAI) score at baseline and at 6 and 12-month follow-up appointments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results showed no statistically significant difference in the radiographic healing rates between the two groups at either follow-up period. The success rates (PAI score \u22642) were 93.3% for the single-visit group and 86.7% for the multiple-visit group at 12 months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest that both treatment protocols are equally effective in achieving periapical healing, challenging the necessity of an inter-appointment intracanal medicament.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1567_25","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:00:30Z","timestamp":1769158830000},"page":"S206-S208","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Radiographic Evaluation of Periapical Healing Following Single vs Multiple Visit Root Canal Treatment: A PAI Based Study"],"prefix":"10.4103","volume":"18","author":[{"given":"Charan Teja","family":"Bobba","sequence":"first","affiliation":[{"name":"Private Practitioner, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita Grace","family":"Vijay","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Sri Aurobindo College of Dentistry, Sri Aurobindo University, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Aher","sequence":"additional","affiliation":[{"name":"Department Oral Medicine and Radiology, Megascan Imaging Centre Vashi, Vashi, Navi Mumbai, Maharastra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaskaran","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Desh Bhagat Dental College and Hospital, Mandi Gobindgarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayushi","family":"Kejriwal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, IMS, BHU, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Mahatma Gandhi Postgraduate Institute of Dental sciences, Government of Puducherry Institution, Gorimedu, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, University of Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1007\/s00784-014-1198-1","article-title":"Clinical investigation of bacterial species and endotoxin in endodontic infection and evaluation of root canal content activity against macrophages by cytokine production","volume":"18","author":"Martinho","year":"2014","journal-title":"Clin Oral Investig"},{"key":"R2-20260310","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0099-2399(06)81169-6","article-title":"Endodontic treatment of teeth with apical periodontitis: Single vs. multivisit treatment","volume":"25","author":"Trope","year":"1999","journal-title":"J Endod"},{"key":"R3-20260310","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/2141-9248.180265","article-title":"Single versus multi-visit endodontic treatment of teeth with apical periodontitis: An in vivo Study with 1-year evaluation","volume":"6","author":"Gill","year":"2016","journal-title":"Ann Med Health Sci Res"},{"key":"R4-20260310","first-page":"149","article-title":"Radiographic quality of single vs. multiple-visit root canal treatment performed by dental students: A case control study","volume":"13","author":"Al-Manei","year":"2018","journal-title":"Iran Endod J"},{"key":"R5-20260310","first-page":"45","article-title":"A systematic review of nonsurgical single-visit versus multiple-visit endodontic treatment","volume":"6","author":"Wong","year":"2014","journal-title":"Clin Cosmet Investig Dent"},{"key":"R6-20260310","first-page":"268","article-title":"Effects of clinical training and case difficulty on the radiographic quality of root canal fillings performed by dental students in Saudi Arabia","volume":"10","author":"Alsulaimani","year":"2015","journal-title":"Iran Endod J"},{"key":"R7-20260310","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.joen.2017.01.021","article-title":"Endodontic treatment in single and multiple visits: An overview of systematic reviews","volume":"43","author":"Moreira","year":"2017","journal-title":"J Endod"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1567_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:25:21Z","timestamp":1786724721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1567_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":7,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1567_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"2025-09-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}