{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:25:22Z","timestamp":1787772322213,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aimed to compare the healing outcomes of periapical lesions with different histopathological features, focusing on the effectiveness of nonsurgical endodontic therapy versus surgical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>\n                      This observational study compared the healing of histologically confirmed periapical lesions after nonsurgical or surgical treatment. Patients were followed for \u226512 months. Healing was assessed clinically and radiographically at 6 and 12 months and classified as complete, incomplete, or no healing. Chi-square tests compared outcomes between treatment groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Analysis revealed that nonsurgical management showed high success in periapical granulomas and pocket cysts, whereas surgical approaches provided superior outcomes in true cysts and persistent lesions. A comparative table demonstrated that complete healing was significantly more predictable when treatment modality was tailored to the lesion\u2019s histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Histopathological differentiation of periapical lesions plays a critical role in guiding treatment strategy. While nonsurgical therapy remains effective for most inflammatory lesions, surgical intervention is more beneficial for true cysts, underscoring the importance of lesion-specific management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1584_25","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:00:19Z","timestamp":1771063219000},"page":"S159-S161","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Healing Outcomes of Periapical Lesions with Different Histopathological Features Following Endodontic versus Surgical Management"],"prefix":"10.4103","volume":"18","author":[{"given":"Osama Magdy","family":"Monir Mostafa","sequence":"first","affiliation":[{"name":"Department of Conservative and Endodontics, Almoosa Specialist Hospital, Alahsa, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita Pankaj","family":"Sonwane","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, D. Y. Patil Dental School Lohegaon, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish","family":"Muzaffar","sequence":"additional","affiliation":[{"name":"Department of Dentistry, SEGi University, Petaling Jaya, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrunal","family":"Dave","sequence":"additional","affiliation":[{"name":"Bethlehem Smile Design, Bethlehem, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyatam","family":"Karade","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Sangli, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medum Shabharish","family":"Shyam Kumar","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, G. Pulla Reddy Dental College and Hospital, G. P. R. Nagar, Kurnool, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iram","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Kothiwal Dental College and Research Institute, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1046\/j.1365-2591.1998.00146.x","article-title":"New perspectives on radicular cysts: Do they heal?","volume":"31","author":"Nair","year":"1998","journal-title":"Int Endod J"},{"key":"R2-20260310","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1079-2104(96)80156-9","article-title":"Types and incidence of human periapical lesions obtained with extracted teeth","volume":"81","author":"Ramachandran","year":"1996","journal-title":"Oral Surg Oral Med Oral Pathol 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