{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:46:06Z","timestamp":1790102766452,"version":"4.0.1"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute pancreatitis (AP) is a sudden inflammatory process of the pancreas that can lead to varying degrees of severity, ranging from mild discomfort to life-threatening conditions. Identifying key inflammatory markers at an early stage is crucial to predicting clinical outcomes and improving management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aims to evaluate the association between inflammatory markers\u2014C-reactive protein (CRP), serum amylase, and white blood cell (WBC) count\u2014and clinical outcomes in patients with acute pancreatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective cohort study involving 120 patients diagnosed with AP was conducted. Inflammatory markers were measured at admission, and their relationship with clinical outcomes, including hospital stay, severity of pancreatitis, and complications, was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Elevated CRP and WBC count were associated with severe pancreatitis and poor outcomes. Serum amylase showed no significant correlation with the severity of the disease. CRP was the strongest predictor of prolonged hospital stay and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CRP is a reliable inflammatory marker for predicting severe clinical outcomes in AP, suggesting its use for routine monitoring in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1586_24","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:00:27Z","timestamp":1750208427000},"page":"S1194-S1196","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Inflammatory Markers and Clinical Outcomes in Patients with Acute Pancreatitis: A Prospective Cohort Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Mruga Malay","family":"Dhebar","sequence":"first","affiliation":[{"name":"Department of Cardiology, Wythenshawe Hospital, MFT, Wythenshawe, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Likhitha","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Madras Medical College, EVR Periyar Salai, Near G H Hospital, Park Town, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore Kumar","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Academics, Marrow Daily Rounds, Dollars Colony, J P Nagar, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AP Aravinda Sathya","family":"Seelan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sri Madhusudan Sai Institute of Medical Sciences and Research, SMSIMSR, Sathya Sai Grama, Muddenahalli, Dist. Chikkaballapur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Manikandan","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Madras Medical College, EVR Periyar Salai, Near G H Hospital, Park Town, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswin","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Madras Medical College, EVR Periyar Salai, Near G H Hospital, Park Town, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh Chandulal","family":"Shingala","sequence":"additional","affiliation":[{"name":"Department of General Medicines, HCG Hospitals, Ayodhya Chowk, HCG Hospital Road, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmitha","family":"Rameshbabu","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Madras Medical College, EVR Periyar Salai, Near G H Hospital, Park Town, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Prashanth","sequence":"additional","affiliation":[{"name":"Department of Physiology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","first-page":"2018092","article-title":"Fluid resuscitation in acute pancreatitis","author":"Aggarwal","year":"2014","journal-title":"World J Gastroenterol"},{"key":"R2-20250618","first-page":"e39515","article-title":"Comparing prognostic scores and inflammatory markers in predicting the severity and mortality of acute pancreatitis","volume":"15","author":"Jain","year":"2023","journal-title":"Cureus"},{"key":"R3-20250618","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3390\/ijms18020354","article-title":"The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications","volume":"18","author":"Dumnicka","year":"2017","journal-title":"Int J Mol Sci"},{"key":"R4-20250618","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3892\/etm.2023.12272","article-title":"Treatment and diagnosis of hyperlipidemia acute pancreatitis in pregnancy associated with prepregnancy obesity and diabetes: A case report","volume":"26","author":"Cao","year":"2023","journal-title":"Exp Ther Med"},{"key":"R5-20250618","first-page":"e26","article-title":"Genetic predictors of azathioprine toxicity and clinical response in patients with inflammatory bowel disease","volume":"23","author":"Al-Judaibi","year":"2016","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"R6-20250618","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12876-023-02837-w","article-title":"Clinical significance of reactive thrombocytosis in the course of acute pancreatitis","volume":"23","author":"Chiba","year":"2023","journal-title":"BMC Gastroenterol"},{"key":"R7-20250618","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/MPA.0000000000000957","article-title":"Comparison of various scoring systems and biochemical markers in predicting the outcome in acute pancreatitis","volume":"47","author":"Vasudevan","year":"2018","journal-title":"Pancreas"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1586_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:39Z","timestamp":1787836959000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1586_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":7,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1586_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-11-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}