{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:59Z","timestamp":1787775839317,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Mifepristone results in cervical ripening in females undergoing pregnancy termination. It causes cervical ripening via blockage of progesterone receptors.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The present study aimed to assess the safety and efficacy of oral Mifepristone for cervical ripening in single-live intrauterine term unscarred pregnancies.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The present study assessed 200 single live-term intrauterine unscarred pregnancies. All were induced using oral mifepristone in 400 mg dose after assessment of BS. A reassessment of BS was done after 24 hours and if needed (in BS < 6), 0.5 mg instilled dinoprostone was given intracervical in 1\u20133 doses at 6-hour intervals. In BS > 6, subjects were sent to the labor room for oxytocin infusion and ARM, if needed. BS gains after 24 hours, perinatal outcomes, delivery route, and induction to delivery interval were assessed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean birth weight in study subjects was 2862.5 \u00b1 85.2 grams. delivery mode was cesarean, outlet forceps delivery, ventouse delivery, and normal delivery in 8.5% (\n n<\/jats:italic>\n = 17), 1.55% (\n n<\/jats:italic>\n = 3), 3% (\n n<\/jats:italic>\n = 6), and 87% (\n n<\/jats:italic>\n = 174) study subjects respectively. Asphyxia or need for admission to NICU was reported in 4% (n = 8) of study subjects. re was 0.5% (\n n<\/jats:italic>\n = 1) perinatal death in the study. Mean APGAR scores at the 1\n st<\/jats:sup>\n and 5\n th<\/jats:sup>\n minute were 8 and 9 respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Mifepristone is efficacious and safe for inducing labor and cervical ripening in subjects with full-term pregnancy.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1599_24","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:00:07Z","timestamp":1744862407000},"page":"S730-S732","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Efficacy of Oral Mifepristone for Cervical Ripening in Single Live Intrauterine Term Unscarred Pregnancies"],"prefix":"10.4103","volume":"17","author":[{"given":"Sarika","family":"Rawat","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Dr. Laxmi Narayan Pandey Government Medical College, Ratlam, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Hedau","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Mahatma Gandhi Memorial Government Medical College, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avani","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Dr. Laxmi Narayan Pandey Government Medical College, Ratlam, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti","family":"Mandloi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonu","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5455\/2320-1770.ijrcog20130206","article-title":"Effect of mifepristone in cervical ripening for induction of labor","volume":"2","author":"Athawale","year":"2013","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0301-2115(00)00506-6","article-title":"The effects of mifepristone on uterine sensitivity to oxytocin and on fetal heart rate patterns","volume":"97","author":"Giacalone","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijgo.2006.09.030","article-title":"Mifepristone and misoprostol in induction of labor at term","volume":"96","author":"McGill","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"key":"R4-20250513","article-title":"Mifepristone for induction of labour","volume":"3","author":"Hapangama","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"R5-20250513","first-page":"164","article-title":"Mifepristone in induction of labor at term","volume":"4","author":"Fathima","year":"2013","journal-title":"Int J of Pham Biomed Res"},{"key":"R6-20250513","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0968-8080(08)31371-8","article-title":"Second-trimester medical abortion with mifepristone-misoprostol and misoprostol alone: A review of methods and management","volume":"16","author":"Gemzell-Danielsson","year":"2008","journal-title":"Reproduct Health Matters"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ajog.2004.05.084","article-title":"Use of mifepristone to ripen cervix and induce labor in term pregnancies","volume":"192","author":"Berkane","year":"2005","journal-title":"A J Obstet Gynecol"},{"key":"R8-20250513","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004901.pub2","article-title":"Misoprostol for induction of labor to terminate pregnancy in second or third trimester for women with a fetal anomaly or after intrauterine fetal death","author":"Dodd","year":"2010","journal-title":"Cochrane Database Syst Rev 2010"},{"key":"R9-20250513","first-page":"348","article-title":"A comparative study of mifepristone alone versus mifepristone and misoprostol for induction of labor in intrauterine fetal death","volume":"3","author":"Ahuja","year":"2016","journal-title":"Indian J Obstet Gynecol Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1599_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:42Z","timestamp":1787773422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1599_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":9,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1599_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2024-11-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}