{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:04:22Z","timestamp":1790006662845,"version":"4.0.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Isotretinoin is used to treat severe, disfiguring nodular acne. It is effective against acne vulgaris and its systemic adverse effects are documented, but there is limited research on oral side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the oral side effects associated with isotretinoin therapy in patients diagnosed with acne vulgaris. Particular attention was given to manifestations such as cheilitis, xerostomia, mucosal ulcerations, and gingival changes, as these may affect patient comfort and adherence to therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A prospective study was conducted on 60 patients receiving oral isotretinoin. Comprehensive oral examinations were performed at baseline and repeated at regular intervals throughout the treatment period to monitor for the onset, type, and severity of oral adverse effects. Patient-reported symptoms were also recorded to complement clinical observations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Cheilitis was the most frequently observed oral side effect, occurring in 45 patients (75%), followed by xerostomia in 30 patients (50%). Less frequent manifestations included mucosal ulcerations (16.7%) and gingival changes (13.3%). All adverse effects were generally mild to moderate in severity and were effectively managed with supportive care without interrupting therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Oral side effects of isotretinoin therapy are predictable, primarily mild to moderate, and manageable with appropriate care. Early recognition, preventive measures, and patient education can minimize discomfort and ensure adherence, allowing patients to safely benefit from the therapeutic effects of isotretinoin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1600_25","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:00:34Z","timestamp":1769158834000},"page":"S165-S167","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Oral Side Effects of Isotretinoin Therapy in Acne Patients: A Prospective Study"],"prefix":"10.4103","volume":"18","author":[{"given":"Reem M.","family":"Alqahtani","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Alatwi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Almohammed Jinan","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Alruwaili Danah","family":"Naif","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Alruwaili Almas","family":"Naif","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Alqhtani Rahaf","family":"Mshabab","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesam Ziad","family":"Alanazi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4103\/1119-3077.183248","article-title":"The oral adverse effects of isotretinoin treatment in acne vulgaris patients: A prospective, case-control study","volume":"20","author":"Erdemir","year":"2017","journal-title":"Niger J Clin Pract"},{"key":"R2-20260310","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2147\/CCID.S234231","article-title":"Challenges and solutions in oral isotretinoin in acne: Reflections on 35 years of experience","volume":"12","author":"Bettoli","year":"2019","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"R3-20260310","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.3390\/ijerph19116463","article-title":"Adverse events in isotretinoin therapy: A single-arm meta-analysis","volume":"19","author":"Kapa\u0142a","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"R4-20260310","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4103\/0378-6323.86482","article-title":"Oral isotretinoin in different dose regimens for acne vulgaris: A randomized comparative trial","volume":"77","author":"Agarwal","year":"2011","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R5-20260310","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1080\/09546634.2021.1967269","article-title":"Isotretinoin for acne vulgaris-An update on adverse effects and laboratory monitoring","volume":"33","author":"Fallah","year":"2022","journal-title":"J Dermatolog Treat"},{"key":"R6-20260310","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.2147\/CCID.S416267","article-title":"Physiological and psychological effects of isotretinoin in the treatment of patients with acne: A narrative review","volume":"16","author":"Ding","year":"2023","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"R7-20260310","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13048-024-01347-x","article-title":"The impact of oral isotretinoin on ovarian functions of acne patients complaining of polycystic ovarian syndrome: A prospective study","volume":"17","author":"Elnagar","year":"2024","journal-title":"J Ovarian Res"},{"issue":"Suppl 1","key":"R8-20260310","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.abd.2020.09.001","article-title":"Consensus on the use of oral isotretinoin in dermatology-Brazilian Society of Dermatology","volume":"95","author":"Bagatin","year":"2020","journal-title":"An Bras Dermatol"},{"key":"R9-20260310","first-page":"E1","article-title":"A systematic review of isotretinoin dosing in acne vulgaris","volume":"16","author":"Daly","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R10-20260310","doi-asserted-by":"crossref","first-page":"7714527","DOI":"10.1155\/2024\/7714527","article-title":"Knowledge, attitude, and risk perception in oral isotretinoin use: A cross-sectional study from Jordan","volume":"2024","author":"Al-Hawamdeh","year":"2024","journal-title":"Dermatol Res Pract"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1600_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:01:42Z","timestamp":1787760102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1600_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":10,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1600_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"2025-09-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}