{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:04:00Z","timestamp":1787169840763,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Type 2 Diabetes Mellitus (T2DM) is increasingly recognized as a risk factor for skeletal fragility, independent of bone mineral density (BMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This prospective, cross-sectional case-control study investigated bone geometry using peripheral quantitative computed tomography (pQCT) in 100 patients with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>100 cases of Type 2 DM and healthy cohorts were compared for bone geometry at a tertiary care hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Trabecular density was notably reduced in men, while both periosteal and endosteal circumferences were significantly diminished in both sexes, suggesting cortical thinning and compromised bone geometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings suggest that pQCT provides valuable insights into microarchitectural deficits, explaining the increased fracture risk in T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1601_25","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:00:54Z","timestamp":1767013254000},"page":"S3624-S3626","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Altered Bone Geometry and Quality in Type 2 Diabetes Mellitus: Insights from Peripheral Quantitative Computed Tomography in an Indian Cohort"],"prefix":"10.4103","volume":"17","author":[{"given":"Anuradha V.","family":"Khadilkar","sequence":"first","affiliation":[{"name":"Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Divate","sequence":"additional","affiliation":[{"name":"Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwajit","family":"Satale","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Jehangir Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajit S.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Medical Administration, Jehangir Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikanth","family":"Muralidharan","sequence":"additional","affiliation":[{"name":"Department of Medical Administration, Jehangir Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"R3-20260217","first-page":"2","article-title":"Epidemiology of fractures in type 2 diabetes","volume":"82","author":"Schwartz","year":"2016","journal-title":"J Bone Miner Res"},{"key":"R4-20260217","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.berh.2014.01.002","article-title":"Osteoporosis and fragility fractures:Vertebral fractures","volume":"27","author":"Gerdhem","year":"2013","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"R5-20260217","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nrendo.2016.153","article-title":"Mechanisms of diabetes mellitus-induced bone fragility","volume":"13","author":"Napoli","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"R6-20260217","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1210\/jc.2006-0614","article-title":"Risk of fracture in 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BMD registry","volume":"33","author":"Leslie","year":"2018","journal-title":"J Bone Miner Res"},{"key":"R10-20260217","first-page":"2650342","article-title":"Diabetic bone disease and diabetic myopathy:Manifestations of the impaired muscle-bone unit in type 1 diabetes","author":"Travis","year":"2022","journal-title":"J Diabetes Res. 2022"},{"key":"R11-20260217","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s11914-022-00755-6","article-title":"Meta-analysis of diabetes mellitus-associated differences in bone structure assessed by high-resolution peripheral quantitative computed tomography","volume":"20","author":"Walle","year":"2022","journal-title":"Curr Osteoporos Rep"},{"key":"R12-20260217","first-page":"e14514","article-title":"Systematic review:Are the elderly with diabetes mellitus type 2 prone to fragility fractures?","volume":"13","author":"Papaioannou","year":"2021","journal-title":"Cureus"},{"key":"R13-20260217","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3390\/ijerph22060910","article-title":"The effect of type 2 diabetes on bone quality:A systematic review and meta-analysis of cohort studies","volume":"22","author":"Ojo","year":"2025","journal-title":"Int J Environ Res Public Health"},{"key":"R14-20260217","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1210\/clinem\/dgab061","article-title":"In men with obesity, T2DM is associated with poor trabecular microarchitecture and bone strength and low bone turnover","volume":"106","author":"Vigevano","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"R15-20260217","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/biom12040542","article-title":"Advanced glycation end products and diabetes mellitus:Mechanisms and perspectives","volume":"12","author":"Khalid","year":"2022","journal-title":"Biomolecules"},{"key":"R16-20260217","doi-asserted-by":"crossref","first-page":"e10832","DOI":"10.1002\/jbm4.10832","article-title":"Microvascular disease associates with larger osteocyte lacunae in cortical bone in type 2 diabetes mellitus","volume":"7","author":"Zanner","year":"2023","journal-title":"JBMR Plus"},{"key":"R17-20260217","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1210\/jc.2016-1437","article-title":"Advanced glycation endproducts and bone material strength in type 2 diabetes","volume":"101","author":"Furst","year":"2016","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Pharmacy and Bioallied 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