{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:56:47Z","timestamp":1791212207534,"version":"4.1.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"\n Background:<\/jats:title>\n Periodontal diseases are a group of inflammatory diseases causing alveolar bone loss and eventually leading to loss of teeth. The present study was evaluated the effectiveness of platelet-rich fibrin (PRF) in the treatment of intrabony defects with or without bone graft.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Thirty subjects with the presence of intrabony defects were enrolled. All subjects were included irrespective of age and gender. A questionnaire was prepared for extracting demographic and personal details of all the patients. William probe and moth mirror-tweezers set was used for carrying out clinical examination of all subjects. Random and unbiased division of all the subjects was done with ten patients in each group as follows: Group I: Subjects in which treatment was carried out using PRF with demineralized bone matrix, Group II: Subjects in which treatment was carried out using PRF alone, and Group III: Subjects in which treatment was carried in the form of open flap debridement (OFD). Pretreatment and posttreatment clinical variables were assessed which included plaque index (PI), gingival index (GI), probing depth (PD), relative attachment level (RAL), and gingival recession (GR) were assessed at baseline and 9 months postoperatively were calculated.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Mean PI among Group 1, Group 2, and Group 3 at baseline was 0.78, 0.8, and 0.84, respectively. Mean PI among Group 1, Group 2, and Group 3 at 9 months follow-up was 0.56, 0.55, and 0.72, respectively. Significant results were obtained while comparing the PI among the three study groups at follow-up. Mean GI among Group 1, Group 2, and Group 3 at baseline was 0.78, 0.8, and 0.84, respectively. Mean GI among Group 1, Group 2, and Group 3 at 9 months follow-up was 0.56, 0.55, and 0.72, respectively. Significant results were obtained while comparing the GI among the three study groups at follow-up. Significant difference was seen in PD, RAL, and GR from baseline to 9 months in all groups (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n PRF leads to significantly better improvement in the clinical parameters on follow-up in comparison to OFD alone in patients with the presence of intrabony defects.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_161_21","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T06:05:28Z","timestamp":1675836328000},"page":"S1350-S1353","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of Platelet-Rich Fibrin in the Treatment of Intrabony Defects with or Without Bone Graft: A Clinical Comparative Study"],"prefix":"10.4103","volume":"13","author":[{"given":"Mohammed Ahsan","family":"Razi","sequence":"first","affiliation":[{"name":"Department of Periodontology, Hazaribag College of Dental Sciences and Hospital, Hazaribag, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shandar","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Pedodontics and Preventive Dentistry, Patna Health Care, Sabzibagh, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Government Dental College, Shimla, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Qamar","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Hazaribag College of Dental Sciences and Hospital, Hazaribag, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Hazaribag College of Dental Sciences and Hospital, Hazaribag, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soni","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Hazaribag College of Dental Sciences and Hospital, Hazaribag, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"R1-20250920","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tripleo.2005.07.009","article-title":"Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: Platelet-related biologic features","volume":"101","author":"Dohan Ehrenfest","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R2-20250920","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1902\/jop.2014.140373","article-title":"Antimicrobial activity of platelet-rich plasma and other plasma preparations against periodontal pathogens","volume":"86","author":"Yang","year":"2015","journal-title":"J Periodontol"},{"key":"R3-20250920","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fphys.2015.00290","article-title":"The influence of platelet-derived products on angiogenesis and tissue repair: A concise update","volume":"6","author":"Martinez","year":"2015","journal-title":"Front Physiol"},{"key":"R4-20250920","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/1305-7456.149653","article-title":"Evaluation of intrabony defects treated with platelet-rich fibrin or autogenous bone graft: A comparative analysis","volume":"9","author":"Mathur","year":"2015","journal-title":"Eur J Dent"},{"key":"R5-20250920","first-page":"86","article-title":"Efficacy of platelet-rich fibrin vs. enamel matrix derivative in the treatment of periodontal intrabony defects: A clinical and cone beam computed tomography study","volume":"16","author":"Gupta","year":"2014","journal-title":"J Int Acad Periodontol"},{"key":"R6-20250920","first-page":"32","article-title":"Comparative evaluation of platelet-rich fibrin biomaterial and open flap debridement in the treatment of two and three wall intrabony defects","volume":"7","author":"Ajwani","year":"2015","journal-title":"J Int Oral Health"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/jicd.12117","article-title":"Additive effect of autologous platelet concentrates in treatment of intrabony defects: A systematic review and meta-analysis","volume":"7","author":"Panda","year":"2016","journal-title":"J Investig Clin Dent"},{"key":"R8-20250920","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.11607\/jomi.4414","article-title":"Experimental evaluation of the effectiveness of demineralized bone matrix and collagenated heterologous bone grafts used alone or in combination with platelet-rich fibrin on bone healing in sinus floor augmentation","volume":"31","author":"Peker","year":"2016","journal-title":"Int J Oral Maxillofac Implants"},{"key":"R9-20250920","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1902\/jop.2004.75.3.399","article-title":"Radiographic parameters for prognosis of periodontal healing of infrabony defects: Two different definitions of defect depth","volume":"75","author":"Eickholz","year":"2004","journal-title":"J Periodontol"},{"key":"R10-20250920","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tripleo.2005.07.008","article-title":"Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R11-20250920","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.4103\/2231-0762.189753","article-title":"Efficacy of platelet rich fibrin in the treatment of human intrabony defects with or without bone graft: A randomized controlled trial","volume":"6","author":"Chandradas","year":"2016","journal-title":"J Int Soc Prev Community Dent"},{"key":"R12-20250920","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/2231-0762.159956","article-title":"Clinical and radiographic evaluation of periodontal intrabony defects by open flap surgery alone or in combination with Biocollagen(\u00ae) membrane: A randomized clinical trial","volume":"5","author":"Elkhatat","year":"2015","journal-title":"J Int Soc Prev Community Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_161_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:51:44Z","timestamp":1787838704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_161_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":12,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_161_21","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"2021-03-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}