{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:23:55Z","timestamp":1787757835422,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Parenteral testosterone has been used to increase glans diameter and penis size before hypospadias surgery. However, the existing literature data are scarce in the Indian context.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The present study aimed to assess the efficacy of parenteral testosterone injection on diameter at the base of the penis, glans diameter, and penile length before surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The study assessed 40 hypospadia subjects who were given testosterone propionate injection a 2 mg\/kg body weight dose given deep intramuscularly in three doses at 3-week gap before reconstructive surgery. Before surgery, diameter at the base of the penis, glans diameter, and penile length was assessed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The study results showed a mean increase in diameter at the base of the penis, glans diameter, and penile length after parenteral testosterone therapy as 0.94 \u00b1 0.14, 1.03 \u00b1 0.48, and 1.09 \u00b1 0.25, respectively. All three factors were statistically significant with\n P<\/jats:italic>\n < 0.001.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Intramuscular testosterone injection leads to an increase in diameter at the base of the penis, glans diameter, and penile length without any notable associated severe side effects. However, minor side effects are associated, including aggressiveness, acne, and fine pubic hair development.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1628_24","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:00:12Z","timestamp":1744862412000},"page":"S742-S744","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the Efficacy of Parental Testosterone Therapy in the Penis Size Before Hypospadias Surgery"],"prefix":"10.4103","volume":"17","author":[{"given":"Praveen S.","family":"Baghel","sequence":"first","affiliation":[{"name":"Department of General Surgery, Dr. Laxmi Narayan Pandey Government Medical College, Ratlam Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Dawar","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr. Laxmi Narayan Pandey Government Medical College, Ratlam Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Mandloi","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. Laxmi Narayan Pandey Government Medical College, Ratlam Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarika","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Dr. Laxmi Narayan Pandey Government Medical College, Ratlam Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonu","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/0971-9261.194610","article-title":"Pediatric penile and glans anthropometry nonograms: An aid in hypospadias management","volume":"22","author":"Puri","year":"2017","journal-title":"J Indian Assoc Pediatr Surg"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jpurol.2019.09.019","article-title":"Assessment of the effect of urethral plate width on outcome of hypospadias repair","volume":"15","author":"Chukwubuike","year":"2019","journal-title":"J Pediatr Urol"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ucl.2010.03.003","article-title":"Hypospadias","volume":"37","author":"Kraft","year":"2010","journal-title":"Urol Clin North Am"},{"key":"R4-20250513","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jpedsurg.2005.11.059","article-title":"Hypospadias: Anatomy, etiology, and technique","volume":"41","author":"Baskin","year":"2006","journal-title":"J Pediatr Surg"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jpurol.2009.11.007","article-title":"Genetic pathway of external genitalia formation and molecular etiology of hypospadias","volume":"6","author":"Kojima","year":"2010","journal-title":"J Pediatr Urol"},{"key":"R6-20250513","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0009922816684613","article-title":"What is hypospadias?","volume":"56","author":"Baskin","year":"2017","journal-title":"Clin Pediatr (Phila)"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.jpurol.2013.05.004","article-title":"Glans penis width in patients with hypospadias compared to healthy controls","volume":"8","author":"Bush","year":"2013","journal-title":"J Pediatr Urol"},{"key":"R8-20250513","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/jpsu.2003.50047","article-title":"Testosterone therapy in microphallic hypospadias: Topical or parenteral?","volume":"38","author":"Chalapathi","year":"2003","journal-title":"J Pediatr Surg"},{"key":"R9-20250513","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/0974-7796.84966","article-title":"Role of parenteral testosterone in hypospadias: A study from a teaching hospital in India","volume":"3","author":"Ahmad","year":"2011","journal-title":"Urol Ann"},{"key":"R10-20250513","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00383-008-2278-6","article-title":"Comparison of topical versus parenteral testosterone in children with microphallic hypospadias","volume":"25","author":"Nerli","year":"2009","journal-title":"Pediatr Surg Int"},{"key":"R11-20250513","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00383-002-0717-3","article-title":"Use of parenteral testosterone before hypospadias surgery","volume":"19","author":"Luo","year":"2003","journal-title":"Pediatr Surg Int"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1628_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:54:08Z","timestamp":1787756048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1628_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":11,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1628_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2024-11-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}