{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:30:50Z","timestamp":1787776250644,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Preeclampsia (PE) is a hypertensive disorder of pregnancy, characterized by high blood pressure (\u2265 140\/90 mmHg), proteinuria, and edema after 20 weeks of gestation. Affecting 3-10% of pregnancies globally, PE is a leading cause of maternal and fetal morbidity and mortality.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This case-control study involved 105 pregnant women in their third trimester (28-40 weeks), divided into three groups: 35 normotensive controls, 35 with mild preeclampsia, and 35 with severe preeclampsia. Serum ceruloplasmin levels were measured using a turbidimetry method on a Biosystem BA400 analyzer. Statistical analysis was performed using SPSS software, with\n P<\/jats:italic>\n values < 0.05 considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The study found significantly higher ceruloplasmin levels in preeclamptic women compared to the control group. Normotensive women had mean ceruloplasmin levels of 84.53 \u00b1 7.33 mg\/dl, while women with mild and severe preeclampsia had levels of 107.44 \u00b1 7.37 mg\/dl and 135.42 \u00b1 10.73 mg\/dl, respectively. The differences were statistically significant (\n P<\/jats:italic>\n < 0.00001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Elevated serum ceruloplasmin levels were strongly associated with the severity of preeclampsia. Early detection of elevated levels may help in diagnosing and managing preeclampsia, potentially reducing maternal and fetal complications.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1630_24","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T14:00:13Z","timestamp":1739628013000},"page":"S638-S641","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Ceruloplasmin as a Vital Tool for Grading of Preeclampsia: A Case-Control Study in Central India"],"prefix":"10.4103","volume":"17","author":[{"given":"Kapil","family":"Raghuwanshi","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Narrey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dileep","family":"Dandotiya","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapnali","family":"Tambade","sequence":"additional","affiliation":[{"name":"Dental Consultant, Chhindwara, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Gandhe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Nursing, Shalinitai Meghe College of Nursing, Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"key":"R1-20250513","first-page":"1","article-title":"Hypertensive disorders of pregnancy","volume":"3","author":"Mammaro","year":"2009","journal-title":"J Prenat Med"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1097\/HJH.0000000000002901","article-title":"Maternal myocardial dysfunction after hemolysis, elevated liver enzymes, and low platelets syndrome:A speckle-tracking study","volume":"39","author":"Sciatti","year":"2021","journal-title":"J Hypertens"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fphys.2014.00372","article-title":"Endothelial dysfunction and preeclampsia:Role of oxidative stress","volume":"5","author":"S\u00e1nchez-Aranguren","year":"2014","journal-title":"Front 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Sci"},{"key":"R8-20250513","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.freeradbiomed.2012.07.013","article-title":"Ceruloplasmin (ferroxidase) oxidizes hydroxylamine probes:Deceptive implications for free radical detection","volume":"53","author":"Ganini","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"R9-20250513","first-page":"42","article-title":"Role of serum ferroxidase activity of ceruloplasmin in preeclampsia","volume":"7","author":"Masti","year":"2018","journal-title":"MedPulse Int J Biochem"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1630_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:01:46Z","timestamp":1787774506000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1630_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,15]]},"references-count":8,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1630_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,15]]},"assertion":[{"value":"2024-11-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}