{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:50Z","timestamp":1787775890724,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>This case study discusses the treatment of primary infertility in a 29-year-old female with a case of polycystic ovarian syndrome (PCOS) who presented to the Infertility Clinic at Wardha, Maharashtra, with a 2-year history of failed conception. The female patient complains about irregular menstrual cycles, mild acne, hair thinning weight gain, and hormonal imbalances characterized by high luteinizing hormone (LH), low levels of follicle-stimulating hormone (FSH), and a raised LH: FSH ratio. Following the initial evaluations, they were put on a comprehensive fertility treatment plan that incorporated Myo-inositol and folic acid supplementation, and seed cycling as a dietary intervention. The seed cycling protocol involved the consumption of ground flaxseeds and pumpkin seeds during the follicular phase and sunflower and sesame seeds during the luteal phase to balance estrogen and progesterone, respectively. After 6 months, the patient experienced notable improvements such as regular menstrual cycles, a reduction in body mass index ranges from 29 to 24 kg\/m\u00b2, normalized hormone levels, and the male partner\u2019s semen analysis representing results within normal limits. The couple moved forward with intracytoplasmic sperm injection, which led to the development of high-quality embryos and a confirmed clinical pregnancy outcome. This case highlights the effectiveness of integrating pharmacological treatment with seed cycling to improve fertility outcomes in patients with PCOS.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_164_25","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T08:00:20Z","timestamp":1744617620000},"page":"S1030-S1033","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Seed Cycling and Hormonal Balance: A Case Study of Successful Fertility Intervention in Polycystic Ovarian Syndrome"],"prefix":"10.4103","volume":"17","author":[{"given":"Puja","family":"Dhamija","sequence":"first","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"More","sequence":"additional","affiliation":[{"name":"Associate Professor, Chief Embryologist, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research Wardha, Maharashtra, India"},{"name":"School of Allied Health Science, Datta Meghe Institute of Higher Education and Research (DU), Sawangi (Meghe), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Choudhary","sequence":"additional","affiliation":[{"name":"School of Allied Health Science, Datta Meghe Institute of Higher Education and Research (DU), Sawangi (Meghe), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejaswini","family":"Wadhe","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhi","family":"Barai","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devanshi","family":"Shah","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3390\/app13021195","article-title":"Image processing approach for grading IVF blastocyst: A state-of-the-art review and future perspective of deep learning-based models","volume":"13","author":"Isa","year":"2023","journal-title":"Appl Sci"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4103\/jhrs.JHRS_140_18","article-title":"Causes and prevalence 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review","volume":"15","author":"Bodepudi","year":"2023","journal-title":"Cureus"},{"key":"R6-20250513","first-page":"281","article-title":"Nutraceutical intervention of seeds in the treatment of poly cystic ovarian syndrome;A systematic review: Nutraceutical intervention;seed cycling","volume":"4","author":"Aslam","year":"2021","journal-title":"Pak BioMed J"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"e1071","DOI":"10.1210\/clinem\/dgaa839","article-title":"Update on PCOS: Consequences, challenges, and guiding treatment","volume":"106","author":"Hoeger","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"R8-20250513","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.mcna.2008.04.008","article-title":"Basic infertility including polycystic ovary syndrome","volume":"92","author":"Brassard","year":"2008","journal-title":"Med Clin North 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