{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:41Z","timestamp":1787840441735,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Restoring the structure and functionality of the periodontal tissues that have been destroyed as a result of illness is the goal of periodontal regeneration. Because it contains growth factors and cytokines, platelet-rich fibrin (PRF) has become a potential regenerative biomaterial that may improve tissue regeneration and repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Procedures:<\/jats:title>\n                    <jats:p>Forty individuals with a diagnosis of chronic periodontitis who were recommended for periodontal regeneration treatment participated in this research. Two groups of patients were randomly assigned: Group A (n = 20) had standard open flap debridement, and Group B (n = 20) received PRF in addition to open flap debridement. At baseline, 3 months, and 6 months after surgery, clinical measures such probing depth (PD), clinical attachment level (CAL), and defect fill were evaluated. Centrifugation was used to create PRF in accordance with conventional procedure, resulting in a fibrin matrix that was enhanced with growth factors and platelets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>When compared to Group A, Group B\u2019s clinical indicators significantly improved after 6 months. Group B\u2019s PD reduction was 3.5 mm \u00b1 0.5, whereas, Group A\u2019s was 2.1 mm \u00b1 0.4. In Group A, the CAL increase was 1.8 mm \u00b1 0.2, whereas, in Group B, it was 3.0 mm \u00b1 0.3. Group B had a 45% \u00b13% bone fill, whereas, Group A had a 28% \u00b1 2% bone fill, according to a radiographic study. Rapid tissue healing was linked to PRF treatment, and there were few postoperative problems noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In comparison to traditional therapies alone, the supplementary use of PRF in periodontal regeneration greatly improves clinical results, demonstrating superior attachment growth, bone fill, and PD reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1652_24","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:01:34Z","timestamp":1750208494000},"page":"S1214-S1216","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Platelet-Rich Fibrin (PRF) in Accelerating Periodontal Regeneration"],"prefix":"10.4103","volume":"17","author":[{"given":"Inderjit Murugendrappa","family":"Gowdar","sequence":"first","affiliation":[{"name":"Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdul Aziz University, Alkharj, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Govt College of Dentistry, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipseeta","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailja","family":"Vediya","sequence":"additional","affiliation":[{"name":"Department of Periodontics, R.R Dental College and Hospital, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Kochar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, MMCDSR, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul Anand","family":"Razdan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Crown and Bridge, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiren H.","family":"Patadiya","sequence":"additional","affiliation":[{"name":"Dental Practice, My Dental Southbridge, Southbridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)","volume":"27","author":"Dohan","year":"2009","journal-title":"Trends Biotechnol"},{"key":"R2-20250618","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1016\/j.biomaterials.2007.06.037","article-title":"The potential impact of the preparation rich in growth factors (PRGF) in different medical fields","volume":"28","author":"Anitua","year":"2007","journal-title":"Biomaterials"},{"key":"R3-20250618","first-page":"55","article-title":"Une nouvelle technique pour la r\u00e9alisation de PRF","volume":"42","author":"Choukroun","year":"2001","journal-title":"Implantodontie"},{"key":"R4-20250618","first-page":"366","article-title":"Evaluation of the regenerative efficacy of platelet-rich fibrin in the management of periodontal intrabony defects","volume":"21","author":"Shah","year":"2017","journal-title":"J Indian Soc Periodontol"},{"key":"R5-20250618","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1902\/jop.2012.110705","article-title":"Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: A randomized controlled clinical trial","volume":"83","author":"Pradeep","year":"2012","journal-title":"J Periodontol"},{"key":"R6-20250618","first-page":"7922","article-title":"Platelet-rich fibrin application in dentistry: A literature review","volume":"8","author":"Borie","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"R7-20250618","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/08977190802636713","article-title":"Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): A gold standard to achieve for all surgical platelet concentrates technologies","volume":"27","author":"Dohan","year":"2009","journal-title":"Growth Factors"},{"key":"R8-20250618","first-page":"407","article-title":"Current knowledge and perspectives for the use of PRF and PRP in oral and maxillofacial surgery: A systematic review","volume":"108","author":"Simonpieri","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1652_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:52Z","timestamp":1787836972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1652_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":8,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1652_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-11-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}