{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:22:14Z","timestamp":1787775734075,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"\n Background:<\/jats:title>\n Dengue fever is a major public health concern in tropical and subtropical regions, including Kerala, India. Hepatic involvement is a common but variable feature of the disease, ranging from asymptomatic transaminitis to acute liver failure.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We conducted a single-center, observational, cross-sectional study over a 6-month period. Adult patients (\u226518 years) with laboratory-confirmed dengue fever (NS1 antigen or IgM ELISA positive) were enrolled consecutively. Detailed clinical and demographic data were collected. Liver function tests, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), were monitored. Hepatic dysfunction was defined as an elevation of AST or ALT >2.5 times the upper limit of normal (>100 IU\/L).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 216 patients were included (mean age 42.5 \u00b1 16.1 years; 56.5% male). The overall incidence of hepatic dysfunction was 64.4% (139\/216). A characteristic pattern of AST elevation greater than ALT was observed, with peak AST levels noted on day 4 of admission. The most common symptoms were fever (100%), myalgia (76.4%), and fatigue (69.9%). Patients with hepatic dysfunction had a significantly longer duration of hospital stay compared to those without (median 5 days vs. 3 days;\n P<\/jats:italic>\n = 0.005). Furthermore, the need for platelet transfusion was significantly higher in the group with hepatic involvement (12.2% vs. 1.3%;\n P<\/jats:italic>\n = 0.005). No mortalities were recorded in the cohort.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Hepatic dysfunction is a frequent complication among hospitalized dengue patients in South Kerala and is associated with a more protracted clinical course, including longer hospital stays and a greater need for platelet transfusions.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1653_25","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T14:02:02Z","timestamp":1768226522000},"page":"S179-S181","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Epidemiological Profile of Liver Dysfunction in Dengue Fever \u2013 A Cross-Sectional Study"],"prefix":"10.4103","volume":"18","author":[{"given":"Maria","family":"Davis","sequence":"first","affiliation":[{"name":"Department of General Medicine, Pushpagiri Institute of Medical Sciences and Research Centre (PIMS and RC), Thiruvalla, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajit","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Pushpagiri Institute of Medical Sciences and Research Centre (PIMS and RC), Thiruvalla, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melbin P.","family":"Thankachan","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Pushpagiri Institute of Medical Sciences and Research Centre (PIMS and RC), Thiruvalla, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"R2-20260310","first-page":"373","article-title":"Dengue in India","volume":"136","author":"Gupta","year":"2012","journal-title":"Indian J Med Res"},{"key":"R3-20260310","doi-asserted-by":"crossref","first-page":"e2564","DOI":"10.1002\/rmv.2564","article-title":"Liver involvement in dengue: A systematic review","volume":"34","author":"Campana","year":"2024","journal-title":"Rev Med Virol"},{"key":"R4-20260310","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.trstmh.2005.10.007","article-title":"Pathogenesis of liver involvement during dengue viral infections","volume":"100","author":"Seneviratne","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"R5-20260310","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12879-016-1656-2","article-title":"Patterns and causes of liver involvement in acute dengue infection","volume":"16","author":"Fernando","year":"2016","journal-title":"BMC Infect Dis"},{"key":"R6-20260310","first-page":"OC01","article-title":"Liver function in dengue and its correlation with disease severity: A study from a tertiary care center in South India","volume":"15","author":"Swamy","year":"2021","journal-title":"J Clin Diagn Res"},{"key":"R7-20260310","first-page":"240","article-title":"An observational study on effect of dengue fever on liver function in patients admitted to a tertiary care centre in Rural South Kerala","volume":"7","author":"Poornima","year":"2019","journal-title":"J Med Sci Clin Res"},{"key":"R8-20260310","first-page":"197","article-title":"A study of clinical profile of dengue fever in Kollam, Kerala, India","volume":"29","author":"Rachel","year":"2005","journal-title":"Dengue Bull"},{"key":"R9-20260310","doi-asserted-by":"crossref","first-page":"125","DOI":"10.12998\/wjcc.v3.i2.125","article-title":"Dengue and its effects on liver","volume":"3","author":"Samanta","year":"2015","journal-title":"World J Clin Cases"},{"key":"R10-20260310","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5365\/wpsar.2011.2.1.002","article-title":"Male-female differences in the number of reported incident dengue fever cases in six Asian countries","volume":"2","author":"Anker","year":"2011","journal-title":"WPSAR"},{"key":"R11-20260310","first-page":"e39436","article-title":"Aminotransferases in relation to the severity of dengue: A systematic review","volume":"15","author":"Kalluru","year":"2023","journal-title":"Cureus"},{"key":"R12-20260310","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/jgh.14927","article-title":"Dengue hepatitis with acute liver failure: Predictors and outcomes","volume":"35","author":"Devarbhavi","year":"2020","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1653_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:40:54Z","timestamp":1787773254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1653_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":11,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1653_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"assertion":[{"value":"2025-10-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}