{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:11:50Z","timestamp":1790403110193,"version":"4.1.0"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    Functional foods incorporating probiotics, essential oils, and DHA, PhosphatidylSerine have been explored as innovative approaches to improving oral health. This study evaluates the effects of consuming two versus five HETAFU candies daily on oral microbial levels over eight weeks. To compare the impact of moderate (two candies\/day) and higher (five candies\/day) HETAFU candy consumption on oral microbial populations, focusing on Streptococcus mutans, Lactobacillus, Actinomycetes, and Candida. A total of 200 participants were randomly divided into two groups: Group 1 consumed two candies daily, and Group 2 consumed five candies daily. Microbial levels were measured at baseline, 2 weeks, 4 weeks, and 8 weeks using microbiological techniques. Statistical analysis included\n                    <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                    scores and\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    values to determine the significance of microbial changes between groups. Both groups showed significant reductions in\n                    <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    , with a concurrent decrease in\n                    <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Actinomycetes<\/jats:italic>\n                    levels over time. However, Group 2 demonstrated greater microbial shifts, indicating enhanced modulation of the oral microbiome with higher candy consumption. Higher consumption of HETAFU candies (five\/day) provides superior benefits in reducing pathogenic microbes and promoting beneficial bacteria compared to moderate consumption (two\/day). This suggests a dose-dependent relationship, with increased intake offering additional protective effects against oral microbial imbalances. Functional foods like HETAFU candies represent a promising adjunct to oral hygiene practices.\n                  <\/jats:p>","DOI":"10.4103\/jpbs.jpbs_16_25","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T03:00:07Z","timestamp":1745550007000},"page":"S133-S136","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Sweet Shield: Enhancing Oral Health with Bioactive HETAFU Candies in Adults \u2013 A Dose-Dependent Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Sowjanya","family":"Lakkoju","sequence":"first","affiliation":[{"name":"Consultant Dental Assistant, R&D Department, Lasarkaali Life Sciences PVT Ltd., Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Bolisetty","sequence":"additional","affiliation":[{"name":"Consultant Dental Assistant, R&D Department, Lasarkaali Life Sciences PVT Ltd., Hyderabad, Telangana, India"},{"name":"Department of Prosthodontics, Crown and Bridge and Implantology, Lasarkaali Life Sciences PVT Ltd., Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjith","family":"Kumar","sequence":"additional","affiliation":[{"name":"Consultant Dental Assistant, R&D Department, Lasarkaali Life Sciences PVT Ltd., Hyderabad, Telangana, India"},{"name":"Oral and Maxillofacial Pathology, Lasarkaali Life Sciences PVT Ltd., Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"issue":"Suppl 1","key":"R2-20250513","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/s12887-021-02702-3","article-title":"Prophylaxis of caries with fluoride for children under five years","volume":"21","author":"Jullien","year":"2021","journal-title":"BMC Pediatrics"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.3390\/ijms24032019","article-title":"Recent advances in health benefits of bioactive compounds from food wastes and by-products: Biochemical aspects","volume":"24","author":"Sorrenti","year":"2023","journal-title":"Int J Mol Sci"},{"key":"R4-20250513","doi-asserted-by":"crossref","first-page":"103643","DOI":"10.1016\/j.jff.2019.103643","article-title":"Probiotic characteristics of Bacillus coagulans and associated implications for human health and diseases","volume":"64","author":"Cao","year":"2020","journal-title":"J Functional Foods"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.1016\/j.sjbs.2021.05.033","article-title":"Using essential oils to overcome bacterial biofilm formation and their antimicrobial resistance","volume":"28","author":"El-Tarabily","year":"2021","journal-title":"Saudi J Biol Sci"},{"key":"R6-20250513","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3733\/ca.v065n03p106","article-title":"Dietary omega-3 fatty acids aid in the modulation of inflammation and metabolic health","volume":"65","author":"Zivkovic","year":"2011","journal-title":"California Agriculture"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3390\/ph16091313","article-title":"The benefits of probiotics on oral health: systematic review of the literature","volume":"16","author":"Inchingolo","year":"2023","journal-title":"Pharmaceuticals"},{"key":"R8-20250513","doi-asserted-by":"crossref","first-page":"1430810","DOI":"10.3389\/fmicb.2024.1430810","article-title":"Probiotics for oral health: A critical evaluation of bacterial strains","volume":"15","author":"Beattie","year":"2024","journal-title":"Front Microbiol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_16_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:36Z","timestamp":1787773416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_16_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":7,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_16_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"2025-01-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}