{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:30:37Z","timestamp":1786649437061,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To study the success or failure of pregnancy with nifedipine and the side effects of nifedipine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A prospective observational cohort study was conducted on 138 pregnant women between 28 and 34 weeks of gestation, diagnosed with preterm labor. Nifedipine 30 mg was administered orally. The dose was repeated as a maintenance therapy every 6 h for the next two days up to a maximum total dose of 160 mg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Tocolysis was successful in 117 (84.78%) cases. The mode of delivery was vaginal delivery in 131 (94.93%) cases. Side effects of nifedipine were tachycardia in 20 (14.49%) cases, hypotension in 26 (18.84%), and headache in 10 (7.25%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Nifedipine effectively prolonged preterm labor in 84.78% of cases, with 94.93% delivering vaginally with minimal manageable side effects. Overall, nifedipine was a safe and effective tocolytic agent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1706_25","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T17:00:10Z","timestamp":1766422810000},"page":"220-222","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Nifedipine as a Tocolytic Agent in Preterm Labor"],"prefix":"10.4103","volume":"17","author":[{"given":"Neelam","family":"Nalini","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Kujur","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijeta","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medini Rai Medical College and Hospital, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitij Aviraj","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neonatology, AIIMS, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"R1-20251223","first-page":"483","article-title":"Nifedipine as compared to isoxsuprine hydrochloride in preterm labor","volume":"2","author":"Zahir","year":"2015","journal-title":"MedPulse Int Med J"},{"key":"R2-20251223","first-page":"719","article-title":"A comparative study on efficacy of oral nifedipine vs isoxsuprine hydrochloride tocolytics in the prevention of preterm labor in tertiary care hospital, Government Medical College, Ongole","volume":"5","author":"Lakshmi","year":"2023","journal-title":"Int J Acad Med Pharm"},{"key":"R3-20251223","doi-asserted-by":"crossref","first-page":"636","DOI":"10.18203\/2320-1770.ijrcog20170397","article-title":"Our experience of nifedipine as a tocolytic agent in preterm labor (24 weeks to 36 weeks 6 days)","volume":"6","author":"Hangekar","year":"2017","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"R4-20251223","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02109822","article-title":"Treatment of premature labor with the calcium antagonist nifedipine","volume":"229","author":"Ulmsten","year":"1980","journal-title":"Arch Gynecol"},{"key":"R5-20251223","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fphar.2017.00286","article-title":"Discovery and development of calcium channel blockers","volume":"8","author":"Godfraind","year":"2017","journal-title":"Front Pharmacol"},{"key":"R6-20251223","doi-asserted-by":"crossref","first-page":"76","DOI":"10.33545\/gynae.2019.v3.i2b.223","article-title":"Evaluation of nifedipine tocolysis in preterm labor","volume":"3","author":"Sugantha","year":"2019","journal-title":"Int J Clin Obstetr Gynaecol"},{"key":"R7-20251223","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/AOG.0000000000004436","article-title":"Nifedipine for acute tocolysis of preterm labor: A placebo-controlled randomized trial","volume":"138","author":"Hawkins","year":"2021","journal-title":"Obstet Gynecol"},{"key":"R8-20251223","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2147\/IJWH.S159062","article-title":"Effectiveness of nifedipine in threatened preterm labor: A randomized trial","volume":"10","author":"Songthamwat","year":"2018","journal-title":"Int J Womens Health"},{"key":"R9-20251223","doi-asserted-by":"crossref","first-page":"42","DOI":"10.33545\/gynae.2019.v3.i6a.391","article-title":"Comparative study of oral nifedipine tablet and transdermal nitroglycerin patch in preterm labor","volume":"3","author":"Salvi","year":"2019","journal-title":"Int J Clin Obstetr Gynaecol"},{"key":"R10-20251223","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.4103\/jfmpc.jfmpc_1696_20","article-title":"Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study","volume":"11","author":"Ray","year":"2022","journal-title":"J Family Med Prim Care"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1706_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:54:10Z","timestamp":1786647250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1706_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1706_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-11-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}