{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:25:06Z","timestamp":1787775906291,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Cervical stenosis can be congenital or acquired, often resulting from previous surgeries, radiation therapy, or infections. It presents a significant challenge for embryo transfer during in vitro fertilization (IVF) procedures. This case study highlights the successful use of transmyometrial embryo transfer (TMET) as an alternative approach in a patient with severe cervical stenosis, leading to a positive clinical pregnancy outcome. A 36-year-old woman with primary infertility for four years underwent three failed IVF attempts due to severe cervical stenosis. Despite multiple attempts at conventional transcervical embryo transfer, the procedures were unsuccessful, resulting in complications such as cervical bleeding and uterine contractions. Her husband\u2019s semen analysis was normal.Following detailed counseling, the decision was made to proceed with TMET under ultrasound guidance. A catheter was inserted through the myometrium directly into the uterine cavity for embryo placement. The TMET procedure was performed without complications. Embryo transfer was successful, and the patient demonstrated a positive clinical pregnancy outcome. Early pregnancy monitoring revealed appropriate gestational sac development, and no further complications were reported. This case illustrates the effectiveness of TMET in overcoming anatomical barriers caused by cervical stenosis. TMET offers a viable alternative for patients who experience recurrent implantation failure due to failed transcervical transfers. Careful patient selection and the use of ultrasound guidance are essential for maximizing success rates and minimizing complications.Further research and comparative studies are recommended to establish standardized protocols and assess long-term outcomes of TMET in similar cases. TMET proved effective for a patient with severe cervical stenosis, leading to a successful pregnancy. Ultrasound guidance and careful patient selection were key to the procedure\u2019s success.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_173_25","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T02:31:59Z","timestamp":1746066719000},"page":"S1011-S1014","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Overcoming Cervical Stenosis: A Case Study of Transmyometrial Embryo Transfer in Infertility Treatment"],"prefix":"10.4103","volume":"17","author":[{"given":"Devanshi","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"More","sequence":"additional","affiliation":[{"name":"Department of Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Kalaskar","sequence":"additional","affiliation":[{"name":"Department of Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Dhamija","sequence":"additional","affiliation":[{"name":"Department of Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"R1-20250513","first-page":"508","article-title":"Infertility and sexual dysfunctions: A systematic literature review","volume":"58","author":"Starc","year":"2019","journal-title":"Acta Clin Croat"},{"key":"R2-20250513","first-page":"142","article-title":"Difference between Primary and Secondary Infertility in Morocco: Frequencies and Associated Factors","volume":"12","author":"Benksim","year":"2018","journal-title":"Int J Fertil Steril"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00404-023-07126-1","article-title":"Uterine cervical stenosis: From classification to advances in management. Overcoming the obstacles to access the uterine cavity","volume":"309","author":"Vitale","year":"2023","journal-title":"Arch Gynecol Obstet"},{"key":"R4-20250513","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.rbmo.2016.01.008","article-title":"Transmyometrial versus very difficult transcervical embryo transfer: Efficacy and safety","volume":"32","author":"Khairy","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4103\/jhrs.JHRS_88_19","article-title":"Live birth following transmyometrial embryo transfer","volume":"13","author":"Arora","year":"2020","journal-title":"J Hum Reprod Sci"},{"key":"R6-20250513","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0015-0282(16)58292-2","article-title":"Transmyometrial embryo transfer after difficult immediate mock transcervical transfer","volume":"65","author":"Sharif","year":"1996","journal-title":"Fertil Steril"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0015-0282(16)55613-1","article-title":"Transvaginal-transmyometrial embryo transfer: The Towako method;experiences of 104 cases","volume":"59","author":"Kato","year":"1993","journal-title":"Fert Steril"},{"key":"R8-20250513","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.rbmo.2013.09.029","article-title":"Successful twin delivery following transmyometrial embryo transfer in a patient with a false uterine cavity","volume":"28","author":"Mu\u00f1oz","year":"2014","journal-title":"Reprod Biomed Online"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_173_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:45:09Z","timestamp":1787773509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_173_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":8,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_173_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"2025-01-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}