{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:21:38Z","timestamp":1787840498994,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n During ENT procedures, hypotensive anesthesia is essential for enhancing operative vision and reducing blood loss. Both dexmedetomidine and propofol are commonly used medications with different modes of action. The effectiveness of these medicines in producing controlled hypotension during ENT operations is assessed in this research.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Sixty individuals between the ages of 18 and 60 who were having elective ENT operations participated in a prospective randomized clinical study. Patients were split into two groups: 30 patients in Group A got an infusion of propofol, and 30 patients in Group B received an infusion of dexmedetomidine. During surgery, hemodynamic measures such as heart rate (HR) and mean arterial pressure (MAP) were monitored. A visual analog scale (VAS) with a range of 0 (poor) to 10 (excellent) was used to evaluate the quality of the surgical field. Recovery periods were compared, and blood loss was noted. A paired\n t<\/jats:italic>\n -test and Chi-square test were used for statistical analysis, and a significance threshold of\n P<\/jats:italic>\n < 0.05 was established.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean MAP for Group B was 60 \u00b1 4 mmHg (\n P<\/jats:italic>\n < 0.05), while the mean MAP for Group A was 65 \u00b1 5 mmHg. Group A\u2019s mean heart rate was 72 \u00b1 8 bpm, whereas Group B\u2019s was 68 \u00b1 6 bpm (\n P<\/jats:italic>\n = 0.03). Group B\u2019s average surgical field quality VAS score (8.5 \u00b1 0.7) was substantially higher than Group A\u2019s (7.8 \u00b1 0.9) (\n P<\/jats:italic>\n = 0.01). Group B saw a 15% decrease in total blood loss when compared to Group A (\n P<\/jats:italic>\n = 0.04). Group B took 12 \u00b1 3 minutes longer to recover than Group A (10 \u00b1 2 minutes), although the difference was not statistically significant (\n P<\/jats:italic>\n = 0.08).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n During ENT procedures, dexmedetomidine was superior to propofol in terms of lowering intraoperative blood loss, enhancing surgical field quality, and producing controlled hypotension. Its usage, nevertheless, could be linked to somewhat longer recovery periods. In ENT procedures, dexmedetomidine is regarded as an excellent drug for hypotensive anesthesia.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1751_24","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:01:58Z","timestamp":1750208518000},"page":"S1424-S1426","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating Efficiency of Propofol and Dexmedetomidine for Hypotensive Anesthesia in ENT Operations"],"prefix":"10.4103","volume":"17","author":[{"given":"P. Kamesh","family":"Chandra","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, KIMS Seethammadhara, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Kumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Late Shree Lakhiram Agarwal Memorial Government Medical College, Raigarh, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjeet Kumar","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, District Headquarter Hospital, Sundargarh, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Kulmi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, DR. Laxmi Narayan Pandey Government Medical College, Ratlam, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanpal Singh","family":"Makkad","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2165\/00003495-200767070-00007","article-title":"Controlled hypotension:A guide to drug choice","volume":"67","author":"Degoute","year":"2007","journal-title":"Drugs"},{"key":"R2-20250618","first-page":"241","article-title":"Controlled hypotension in children:A critical review of available agents","volume":"20","author":"Tobias","year":"2010","journal-title":"Paediatr Anaesth"},{"key":"R3-20250618","first-page":"921","article-title":"Role of dexmedetomidine in anesthesia and critical care medicine:A clinical review","volume":"24","author":"Ramaswamy","year":"2020","journal-title":"Indian J Crit Care Med"},{"key":"R4-20250618","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.2174\/1381612043382846","article-title":"Propofol:Therapeutic indications and side effects","volume":"10","author":"Marik","year":"2004","journal-title":"Curr Pharm Des"},{"key":"R5-20250618","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s40262-017-0507-7","article-title":"Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine","volume":"56","author":"Weerink","year":"2017","journal-title":"Clin Pharmacokinet"},{"key":"R6-20250618","first-page":"13","article-title":"Dexmedetomidine:A novel sedative-analgesic agent","volume":"14","author":"Gertler","year":"2001","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"R7-20250618","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/oxfordjournals.bja.a013383","article-title":"Patient satisfaction after anaesthesia and surgery:Results of a prospective survey of 10,811 patients","volume":"84","author":"Myles","year":"2000","journal-title":"Br J Anaesth"},{"key":"R8-20250618","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0278-5846(89)90051-1","article-title":"Dexmedetomidine\u2014A novel alpha 2-adrenoceptor agonist:A review of its pharmacodynamic effects","volume":"13","author":"Scheinin","year":"1989","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"R9-20250618","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1365-2044.1997.169-az0303.x","article-title":"Effects of a single pre-operative dexmedetomidine dose on isoflurane requirements and peri-operative haemodynamic stability","volume":"52","author":"Lawrence","year":"1997","journal-title":"Anaesthesia"},{"key":"R10-20250618","first-page":"e31855","article-title":"A Comparative Study to Evaluate the Anesthetic Efficacy of Buffered Versus Non-buffered 2% Lidocaine During Inferior Alveolar Nerve Block","volume":"14","author":"Jain","year":"2022","journal-title":"Cureus"},{"key":"R11-20250618","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4103\/jiaomr.jiaomr_71_19","article-title":"Evaluation of oral health related quality of life in subjects diagnosed with head and neck malignancies undergoing chemotherapy, radiotherapy, and surgery","volume":"31","author":"Naidu","year":"2019","journal-title":"J Indian Acad Oral Med Radiol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1751_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:02Z","timestamp":1787837042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1751_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":11,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1751_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-11-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}