{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:36Z","timestamp":1787840436627,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Periodontal therapy often requires sustained and targeted drug delivery to enhance therapeutic outcomes and minimize systemic side effects. Conventional methods, such as systemic administration and local application, often fail to maintain effective drug concentrations in periodontal pockets.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This study involved the fabrication of sustained-release dental implants composed of biocompatible polymers incorporating antimicrobial agents. Polylactic-co-glycolic acid (PLGA) was used as the primary polymer matrix, and metronidazole was selected as the model drug. Implants were prepared using solvent evaporation techniques and optimized for drug release by altering polymer-to-drug ratios. Characterization of the implants was conducted through scanning electron microscopy (SEM) for surface morphology, differential scanning calorimetry (DSC) for thermal stability, and Fourier-transform infrared spectroscopy (FTIR) for chemical compatibility. Drug release kinetics were analyzed using an\n in vitro<\/jats:italic>\n setup mimicking periodontal conditions over 30 days.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The optimized implants exhibited smooth surfaces with uniform drug distribution. The cumulative drug release profile demonstrated a sustained release of 85% \u00b1 2% of the drug over 30 days, with an initial burst release of 10% \u00b1 1% within the first 24 hours. FTIR and DSC analyses confirmed no chemical interactions or degradation of the drug within the polymer matrix.\n In vitro<\/jats:italic>\n antimicrobial efficacy tests showed a zone of inhibition of 18 \u00b1 1 mm against\n Porphyromonas gingivalis<\/jats:italic>\n for 25 days.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The designed sustained-release dental implants demonstrated excellent potential for targeted periodontal drug delivery, achieving prolonged drug release and effective antimicrobial activity. This approach offers a promising alternative for improving the management of periodontal diseases, reducing systemic drug exposure, and enhancing patient compliance.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_175_25","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:00:56Z","timestamp":1750208456000},"page":"S1604-S1606","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Design and Optimization of Sustained-Release Dental Implants for Targeted Periodontal Drug Delivery"],"prefix":"10.4103","volume":"17","author":[{"given":"Silpi","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daya","family":"Shankar","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Crown and Bridge, Hazaribagh College of Dental Sciences and Hospital, Hazaribag, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yagyesh","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swamini Ajay","family":"Shete","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim Mustafa","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Crown and Bridge, Hazaribagh College of Dental Sciences and Hospital, Hazaribag, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","first-page":"909","article-title":"Polymeric modification and its implication in drug delivery:PLGA-based drug delivery systems","volume":"3","author":"Dash","year":"2012","journal-title":"Ther Deliv"},{"key":"R2-20250618","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.addr.2012.09.004","article-title":"Biodegradation and biocompatibility of PLA and PLGA microspheres","volume":"64","author":"Anderson","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"key":"R3-20250618","first-page":"69","article-title":"Drug delivery for periodontal diseases","volume":"33","author":"Goodson","year":"2006","journal-title":"J Clin Periodontol"},{"key":"R4-20250618","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1875-595X.2004.tb00246.x","article-title":"Topical and systemic antibiotics in the management of periodontal diseases","volume":"54","author":"Mombelli","year":"2004","journal-title":"Int Dent J"},{"key":"R5-20250618","first-page":"186","article-title":"Advances in local drug delivery systems in the treatment of periodontitis:A review","volume":"9","author":"Mishra","year":"2019","journal-title":"J Oral Biol Craniofac Res"},{"key":"R6-20250618","first-page":"78","article-title":"Antimicrobial agents:Effective adjuncts to mechanical therapy in the management of periodontal diseases","volume":"42","author":"Haffajee","year":"2006","journal-title":"Periodontol 2000"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_175_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:42Z","timestamp":1787836962000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_175_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":6,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_175_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}