{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:57Z","timestamp":1787775837847,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Introduction:<\/jats:title>\n Adolescents today suffer from depression due to a range of environmental factors, which have a negative impact on their social, physical, psychological, and cognitive development. This study aims to assess the impact of behavioral activation therapy on neurobiological markers of depression in adolescents.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This study was carried out on school-going adolescents after obtaining informed voluntary consent. 20 adolescents (14-16 years) with mild and moderate depression based on Beck\u2019s Depression Inventory-II (BDI-II) were randomly assigned to control and experimental groups, equally. Behavioral activation therapy was given for 1 month, consisting of mood elevation, problem-solving, social skill development, and healthy behavior, while control was given routine care. Post-test was done using BDI-II for both groups. BMI and salivary cortisol were measured as neurobiological markers for both groups in the pre- and post-test. Data were analyzed through inferential statistics.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Data revealed there is no significant difference in the groups (control and experimental) (\n P<\/jats:italic>\n = .571), no significant difference in tests (pre- and post-test) (\n P<\/jats:italic>\n = .244), and a significant interaction (group X test) (\n P<\/jats:italic>\n = .298). Multiple comparisons found no significant difference between control and experimental pretests (between groups) (\n P<\/jats:italic>\n = .356) or control and experimental post-tests (\n P<\/jats:italic>\n = .9). There was no significant difference between the control pre- and post-test (within groups) (\n P<\/jats:italic>\n = .125) or the experimental pre- and post-test (\n P<\/jats:italic>\n = .926).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Behavioral activation treatment helps to reduce depression among adolescents.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1763_24","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:00:13Z","timestamp":1746849613000},"page":"S561-S564","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Behavioral Activation Therapy on Neurobiological Markers of Depression in Adolescents: A Pilot Study"],"prefix":"10.4103","volume":"17","author":[{"given":"R.","family":"Sindhumathi","sequence":"first","affiliation":[{"name":"PhD Scholar, Department of Mental Health Nursing, Saveetha College of Nursing, Saveetha University, SIMATS, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tamilselvi","sequence":"additional","affiliation":[{"name":"Professor, Department of Community Health Nursing, Saveetha College of Nursing, Saveetha University, SIMATS, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Subash","family":"Jeyagowri","sequence":"additional","affiliation":[{"name":"Department of Child Health Nursing, Principal, College of Nursing, East coast Institute of Medical Sciences, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"R4-20250513","article-title":"Depression in children and adolescents","author":"Tahir","year":"2016","journal-title":"J Clin Case Rep"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mcna.2022.04.005","article-title":"Depression and Suicidal Behavior in Adolescents","volume":"107","author":"Grossberg","year":"2023","journal-title":"Med Clin North Am"},{"key":"R6-20250513","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1016\/S0140-6736(16)00579-1","article-title":"Our future:A lancet commission on adolescent health and wellbeing","volume":"387","author":"Patton","year":"2016","journal-title":"Lancet"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1017\/S0033291714002888","article-title":"A heavy burden on young minds:The global burden of mental and substance use disorders in children and youth","volume":"45","author":"Erskine","year":"2015","journal-title":"Psychol Med"},{"key":"R8-20250513","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1017\/S0033291713003243","article-title":"The global burden of anxiety disorders in 2010","volume":"44","author":"Baxter","year":"2014","journal-title":"Psychol Med"},{"key":"R9-20250513"},{"key":"R10-20250513"},{"key":"R11-20250513"},{"key":"R12-20250513","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/IJPSYM.IJPSYM_5_19","article-title":"Depression in children and adolescents:A review of indian studies","volume":"41","author":"Grover","year":"2019","journal-title":"Indian J Psychol Med"},{"key":"R13-20250513","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s12098-021-03750-4","article-title":"Prevalence of depression in Indian adolescents","volume":"88","author":"Grover","year":"2021","journal-title":"Indian J Pediatr"},{"key":"R14-20250513","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.4103\/jfmpc.jfmpc_2420_21","article-title":"Assessment of mental health status among adolescents in Puducherry, India \u2013A mixed method study","volume":"11","author":"Gunasekaran","year":"2022","journal-title":"J Family Med Prim Care"},{"key":"R15-20250513","doi-asserted-by":"crossref","first-page":"e000624","DOI":"10.1136\/bmjpo-2019-000624","article-title":"Behavioural activation for overweight and obese adolescents with low mood delivered in a community setting:Feasibility study","volume":"4","author":"Arnott","year":"2020","journal-title":"BMJ Paediatr Open"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1763_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:36Z","timestamp":1787773416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1763_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":12,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1763_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-11-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}