{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:40:31Z","timestamp":1787071231885,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background:<\/jats:title>\n \n Denture stomatitis is a common inflammatory condition among removable denture wearers, predominantly associated with\n Candida<\/jats:italic>\n species colonization. Azole antifungal agents remain the mainstay of therapy; however, emerging resistance threatens clinical outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A cross-sectional laboratory-based study was conducted on 80 denture stomatitis patients. Oral swabs from palatal mucosa and denture-fitting surfaces were cultured, and\n Candida<\/jats:italic>\n species were identified using phenotypic methods and CHROMagar. Antifungal susceptibility to fluconazole, itraconazole, ketoconazole, and voriconazole was evaluated using the CLSI broth microdilution method. Data were analyzed using descriptive statistics and Chi-square tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Candida<\/jats:italic>\n species were isolated in 62 of 80 patients (77.5%).\n Candida albicans<\/jats:italic>\n was predominant (64.5%), followed by\n C. tropicalis<\/jats:italic>\n (17.7%),\n C. glabrata<\/jats:italic>\n (12.9%), and\n C. krusei<\/jats:italic>\n (4.9%). Overall susceptibility rates were highest for voriconazole (93.5%) and lowest for fluconazole (71.0%). Fluconazole resistance was significantly higher among non-\n albicans Candida<\/jats:italic>\n species compared to\n C. albicans<\/jats:italic>\n (29.6% vs. 9.8%,\n P<\/jats:italic>\n = 0.018). Mean minimum inhibitory concentration (MIC) values were significantly elevated in non-\n albicans<\/jats:italic>\n isolates (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Azole resistance, particularly to fluconazole, is notable among\n Candida<\/jats:italic>\n isolates from denture stomatitis patients. Routine antifungal susceptibility testing is recommended to guide effective therapy and prevent treatment failure.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1764_25","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:00:20Z","timestamp":1773309620000},"page":"31-33","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Antifungal Susceptibility Assessment of Candida Isolates from Denture Stomatitis Patients to Azole Drugs"],"prefix":"10.4103","volume":"18","author":[{"given":"D.","family":"Vidhyadhar","sequence":"first","affiliation":[{"name":"Department of Dentistry, Kamareddy Government Medical College, Kamareddy, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Chamanthi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, CKS Theja Dental College, Tirupati, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Crown and Bridge, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jayavardhini","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, CKS Theja Dental College, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Vimal","family":"Bharathi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Panineeya Institute of Dental Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swayam S.","family":"Tripathy","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"R1-20260416","first-page":"151","article-title":"The significance of Candida albicans in denture stomatitis","volume":"82","author":"Budtz-J\u00f6rgensen","year":"1974","journal-title":"Scand J Dent Res"},{"key":"R2-20260416","first-page":"1","article-title":"Candida-associated denture stomatitis. Aetiology and management","volume":"4","author":"Webb","year":"1998","journal-title":"Oral Dis"},{"key":"R3-20260416","first-page":"346","article-title":"Mixed Candida species isolates in the oral cavity","volume":"23","author":"Coco","year":"2008","journal-title":"Oral Microbiol Immunol"},{"key":"R4-20260416","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"R5-20260416","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical practice guideline for the management of Candidiasis","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin Infect Dis"},{"key":"R6-20260416","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fmed.2016.00011","article-title":"Emerging threats in antifungal-resistant fungal pathogens","volume":"3","author":"Sanglard","year":"2016","journal-title":"Front Med"},{"key":"R7-20260416","first-page":"3633","article-title":"Inhibition of Candida albicans biofilm formation","volume":"46","author":"Ramage","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"R8-20260416","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1128\/CMR.14.4.643-658.2001","article-title":"Antifungal susceptibility testing: Practical aspects and current challenges","volume":"14","author":"Rex","year":"2001","journal-title":"Clin Microbiol Rev"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1764_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:43:25Z","timestamp":1787067805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1764_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1764_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}