{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:40:32Z","timestamp":1787071232466,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background:<\/jats:title>\n Local drug delivery (LDD) systems have gained prominence in periodontal therapy due to their ability to achieve high drug concentrations at diseased sites while minimizing systemic adverse effects. Sustained-release formulations may further enhance therapeutic efficacy by prolonging drug bioavailability within periodontal pockets.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n This combined\n in-vitro<\/jats:italic>\n \u2013\n in-vivo<\/jats:italic>\n experimental study evaluated a novel biodegradable sustained-release LDD system containing doxycycline hyclate.\n In-vitro<\/jats:italic>\n analysis assessed drug release kinetics, antibacterial efficacy, and biocompatibility.\n In-vivo<\/jats:italic>\n evaluation involved 60 patients with chronic periodontitis randomly allocated to three groups: Group I (scaling and root planing [SRP] + sustained-release doxycycline gel), Group II (SRP + conventional doxycycline gel), and Group III (SRP alone). Clinical parameters, including probing pocket depth (PPD), clinical attachment level (CAL), and gingival index (GI), were recorded at baseline, 1 month, and 3 months.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In-vitro<\/jats:italic>\n testing demonstrated sustained drug release up to 14 days with a cumulative release of 92.6 \u00b1 3.1%. Group I showed significantly greater reductions in PPD (3.1 \u00b1 0.6 mm) and CAL gain (2.8 \u00b1 0.5 mm) at 3 months compared with Group II and Group III (\n P<\/jats:italic>\n < 0.001). Microbial reduction was highest in Group I (78.4%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The novel sustained-release LDD system demonstrated superior\n in-vitro<\/jats:italic>\n release characteristics and enhanced clinical outcomes when used as an adjunct to SRP, supporting its potential role in advanced periodontal therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1767_25","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:00:23Z","timestamp":1773309623000},"page":"43-45","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["In-vitro and In-vivo Assessment of Novel Sustained-release Local Drug Delivery Systems for Periodontal Therapy"],"prefix":"10.4103","volume":"18","author":[{"given":"Ketha","family":"Ramya","sequence":"first","affiliation":[{"name":"Department of Public Health Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Tangade","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna K.","family":"Gudali","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, Government Dental College and Hospital, Kadapa, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swayam S.","family":"Tripathy","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"R1-20260416","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: Facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontol 2000"},{"key":"R2-20260416","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1902\/annals.1996.1.1.443","article-title":"Non-surgical pocket therapy: Mechanical","volume":"1","author":"Cobb","year":"1996","journal-title":"Ann Periodontol"},{"issue":"8 Suppl","key":"R3-20260416","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-051X.2008.01260.x","article-title":"Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm","volume":"35","author":"Herrera","year":"2008","journal-title":"J Clin Periodontol"},{"key":"R4-20260416","first-page":"1625","article-title":"Pharmacokinetic principles controlling efficacy of oral therapy","volume":"68","author":"Goodson","year":"1989","journal-title":"J Dent Res"},{"key":"R5-20260416","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.5005\/jp-journals-10024-1455","article-title":"The use of controlled release locally delivered 10% doxycycline hyclate gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis: clinical and microbiological results","volume":"14","author":"Ahamed","year":"2013","journal-title":"J Contemp Dent Pract"},{"key":"R6-20260416","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3390\/pharmaceutics15041312","article-title":"Local Delivery and Controlled Release Drugs Systems: A New Approach for the Clinical Treatment of Periodontitis Therapy","volume":"15","author":"Amato","year":"2023","journal-title":"Pharmaceutics"},{"key":"R7-20260416","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-051X.1995.tb00120.x","article-title":"Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva","volume":"22","author":"Golub","year":"1995","journal-title":"J Clin Periodontol"},{"key":"R8-20260416","first-page":"39","article-title":"Biodegradable polymers in controlled drug delivery","volume":"1","author":"Heller","year":"1984","journal-title":"Crit Rev Ther Drug Carrier Syst"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1767_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:43:25Z","timestamp":1787067805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1767_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1767_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}