{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:41:24Z","timestamp":1787071284873,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Amyloid-beta plaque and tau tangle buildup lead to Alzheimer\u2019s disease (AD), a brain disorder that causes ongoing mental decline. More and more studies show that oxidative stress plays a crucial role in how AD develops and progresses. This review focuses on presenilin-1 (PSEN1) and F2-isoprostanes, two key indicators of oxidative stress. F2-isoprostanes, which come from damaged fats, appear in much higher levels in people with AD. These substances link to more brain inflammation, nerve cell death, and problems with thinking and memory. Processing of the amyloid precursor protein is dependent on presenilin-1, one of the main components of the \u03b3-secretase complex. It has been shown that mutations in PSEN1, an important gene for familial AD, augment oxidative stress and malfunction of mitochondria, which further aggravates neuronal damage. In this article, the role of F2-isoprostanes and PSEN1 in oxidative stress pathways leading to AD and how their interaction makes the disease worse has been investigated. The contribution of presenilin-1 (PSEN1) and oxidative stress markers, such as F2-isoprostanes, to AD underscores a crucial link in understanding such a complex neurodegenerative pathology. F2-isoprostanes are valuable biomarkers of oxidative stress linked to the severity of illness and cognitive impairment.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1784_24","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T06:03:07Z","timestamp":1742364187000},"page":"S109-S112","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["A Review Article on Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Alzheimer\u2019s Disease"],"prefix":"10.4103","volume":"17","author":[{"given":"Dilip Raj","family":"Timalsina","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Datta Meghe Medical College, Nagpur, Datta Meghe Institute of Higher Education and Research (DU) Sawangi, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leela","family":"Abichandani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Datta Meghe Medical College, Nagpur, Datta Meghe Institute of Higher Education and Research (DU) Sawangi, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Ambad","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Nehru Medical College, Wardha, Datta Meghe Institute of Higher Education and Research (DU) Sawangi, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat Rev Neurosci"},{"issue":"Suppl 1","key":"R3-20250513","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.4103\/0976-500X.120957","article-title":"Clinical and economic burden of adverse drug reactions","volume":"4","author":"Sultana","year":"2013","journal-title":"J Pharmacol Pharmacother"},{"key":"R4-20250513","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev-pharmtox-010814-124309","article-title":"Learning by failing: Ideas and concepts to tackle ?-secretases in Alzheimer's disease and beyond","volume":"55","author":"De Strooper","year":"2015","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S0033291707001638","article-title":"Measuring ideas of persecution and social reference: The Green et al. paranoid thought scales (GPTS)","volume":"38","author":"Green","year":"2008","journal-title":"Psychol Med"},{"key":"R6-20250513","first-page":"240","article-title":"F2-Isoprostanes reflect oxidative stress correlated with lean mass and bone density but not insulin resistance","volume":"2","author":"Ma","year":"2018","journal-title":"[published correction appears in J Endocr Soc]"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0197-4580(98)00009-8","article-title":"Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease","volume":"19","author":"Markesbery","year":"1998","journal-title":"Neurobiol Aging"},{"key":"R8-20250513","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol"},{"key":"R9-20250513","doi-asserted-by":"crossref","first-page":"a006346","DOI":"10.1101\/cshperspect.a006346","article-title":"Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature","volume":"2","author":"Wyss-Coray","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"R10-20250513","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11064-011-0619-7","article-title":"Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: Implications for Parkinson's disease","volume":"37","author":"Venkateshappa","year":"2012","journal-title":"Neurochem Res"},{"key":"R11-20250513","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"R12-20250513","doi-asserted-by":"crossref","first-page":"834962","DOI":"10.3389\/fcell.2022.834962","article-title":"Calcium signaling regulated by cellular membrane systems and calcium homeostasis perturbed in Alzheimer's disease","volume":"10","author":"Huang","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"R13-20250513","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen Res"},{"key":"R14-20250513","doi-asserted-by":"crossref","first-page":"104997","DOI":"10.1016\/j.jbc.2023.104997","article-title":"Pathogenic A? production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1","volume":"299","author":"Kurth","year":"2023","journal-title":"J Biol Chem"},{"key":"R15-20250513","doi-asserted-by":"crossref","first-page":"1281338","DOI":"10.3389\/fnagi.2023.1281338","article-title":"Proteostasis and neurodegeneration: A closer look at autophagy in Alzheimer's disease","volume":"15","author":"Barmaki","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"R16-20250513","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/ars.2005.7.269","article-title":"F2-isoprostanes in Alzheimer and other neurodegenerative diseases","volume":"7","author":"Montine","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"R17-20250513","doi-asserted-by":"crossref","first-page":"8417","DOI":"10.3390\/ijms24098417","article-title":"Presenilin-1 (PSEN1) mutations: Clinical phenotypes beyond Alzheimer's disease","volume":"24","author":"Yang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"R18-20250513","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","article-title":"Oxidative stress and the amyloid beta peptide in Alzheimer's disease","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol"},{"key":"R19-20250513","doi-asserted-by":"crossref","DOI":"10.1002\/0471140856.tx1214s39","article-title":"Measurement of isoprostanes as markers of oxidative stress in neuronal tissue","author":"Milatovic","year":"2009","journal-title":"Curr Protoc Toxicol"},{"key":"R20-20250513","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.taap.2009.07.004","article-title":"Oxidative damage and neurodegeneration in manganese-induced neurotoxicity","volume":"240","author":"Milatovic","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"R21-20250513","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuroscience.2022.12.007","article-title":"Action of the purinergic and cholinergic anti-inflammatory pathways on oxidative stress in patients with Alzheimer's disease in the context of the COVID-19 pandemic","volume":"512","author":"Sim\u00f5es","year":"2023","journal-title":"Neuroscience"},{"key":"R22-20250513","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1212\/WNL.52.3.562","article-title":"Increased CSF F2-isoprostane concentration in probable AD","volume":"52","author":"Montine","year":"1999","journal-title":"Neurology"},{"key":"R23-20250513","doi-asserted-by":"crossref","first-page":"e1002270","DOI":"10.1371\/journal.pmed.1002270","article-title":"APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases","volume":"14","author":"Lanoisel\u00e9e","year":"2017","journal-title":"PLoS Med"},{"key":"R24-20250513","first-page":"572491","article-title":"Isoprostanes and neuroprostanes as biomarkers of oxidative stress in neurodegenerative diseases","author":"Miller","year":"2014","journal-title":"Oxid Med Cell Longev 2014"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1784_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:08Z","timestamp":1787067848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1784_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":24,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1784_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"2024-11-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}