{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:21:47Z","timestamp":1787840507862,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periodontitis is a chronic inflammatory condition that targets the structures supporting the teeth and has been linked to various systemic diseases, particularly cardiovascular conditions. The field of periodontal medicine highlights the influence of periodontitis on overall health, primarily through inflammatory markers such as C-reactive protein (CRP) and fibrinogen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This randomized controlled prospective cohort study included 60 systemically healthy participants aged 30\u201360 years from Modern Dental College and Research Center, Indore. Participants were divided into two groups: Group I (30 periodontally healthy individuals, bleeding on probing (BOP) &lt;20%) and Group II (30 chronic periodontitis patients, probing pocket depth (PPD) \u22654 mm in \u226530% of sites). Exclusion criteria were systemic diseases, smoking, alcohol use, and body mass index (BMI) \u226525 kg\/m\u00b2. Clinical parameters (BOP, PPD, clinical attachment loss (CAL), Vermillion\u2019s Simplified Oral Hygiene Index (OHI-S)) and biochemical markers (CRP, plasma fibrinogen) were measured pre- and post-treatment. Group II received scaling and root planing, with follow-up after three weeks. Data were analyzed using SPSS (IBM corporation, USA), with significance set at\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Group II showed significantly higher BOP (1.00 \u00b1 0.00 vs. 0.22 \u00b1 0.03,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.00) and PPD (5.99 \u00b1 0.55 mm vs. 1.52 \u00b1 0.27 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.00) compared to Group I. After therapy, BOP reduced to 0.31 \u00b1 0.35, PPD to 3.54 \u00b1 1.48 mm, and CAL improved from 6.15 \u00b1 0.51 mm to 3.71 \u00b1 1.49 mm (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.00). Serum CRP in Group II decreased from 1.99 \u00b1 1.05 mg\/L to 1.71 \u00b1 0.62 mg\/L (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.017), and fibrinogen levels dropped from 2.16 \u00b1 0.32 g\/L to 1.86 \u00b1 0.49 g\/L (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Phase I periodontal therapy significantly improved clinical periodontal parameters, including BOP, PPD, and CAL, in patients with chronic periodontitis. The therapy also reduced systemic inflammatory markers, including CRP and fibrinogen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1787_24","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:03:04Z","timestamp":1750208584000},"page":"S1430-S1432","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Effect of Phase 1 Periodontal Therapy on Serum Procoagulant State of Systemically Healthy Chronic Periodontitis Subjects: A Clinico-Biochemical Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Sapna","family":"Raje","sequence":"first","affiliation":[{"name":"Department of Periodontics, Index Institute of Dental Science Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Banthia","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Index Institute of Dental Science Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshita","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Index Institute of Dental Science Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Index Institute of Dental Science Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Modern Dental College and Research Centre, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"issue":"(Suppl 10)","key":"R1-20250618","first-page":"1103","article-title":"Periodontal infection as a possible risk factor for preterm low birth weight","volume":"67","author":"Offenbacher","year":"1996","journal-title":"J Periodontol"},{"issue":"(Suppl 4)","key":"R2-20250618","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-0691.2007.01798.x","article-title":"Relationship between periodontal infections and systemic disease","volume":"13","author":"Seymour","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"R3-20250618","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/prd.12297","article-title":"The role of inflammation and genetics in periodontal disease","volume":"83","author":"Loos","year":"2020","journal-title":"Periodontol 2000"},{"issue":"(Suppl 16)","key":"R4-20250618","first-page":"S5","article-title":"Principles in prevention of periodontal diseases:Consensus report of group 1 of the 11th European Workshop on Periodontology on effective prevention of periodontal and peri-implant diseases","volume":"42","author":"Tonetti","year":"2015","journal-title":"J Clin Periodontol"},{"key":"R5-20250618","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1902\/jop.2012.120040","article-title":"The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole:A systematic review","volume":"84","author":"Zandbergen","year":"2013","journal-title":"J Periodontol"},{"key":"R6-20250618","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.CIR.0000053730.47739.3C","article-title":"Clinical application of C-reactive protein for cardiovascular disease detection and prevention","volume":"107","author":"Ridker","year":"2003","journal-title":"Circulation"},{"key":"R7-20250618","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/jcpe.12171","article-title":"Treatment of periodontitis improves the atherosclerotic profile:A systematic review and meta-analysis","volume":"41","author":"Teeuw","year":"2014","journal-title":"J Clin Periodontol"},{"key":"R8-20250618","first-page":"1799","article-title":"Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality","volume":"294","year":"2005","journal-title":"JAMA"}],"container-title":["Journal of Pharmacy and Bioallied 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