{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:41Z","timestamp":1787775881338,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    This study aimed to identify biomarkers that could enhance the accuracy of diagnosing reversible and irreversible pulpitis. This systematic review was conducted in adherence to the guidelines outlined in PRISMA. A total of twelve studies were included for analysis. A meta-analysis of nine studies showed an overall effect of 9.91 with a\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    value of less than 0.00001. Eight out of the nine studies favored the control group. The studies exhibited substantial variation, with an I-square value of 99%, indicating significant heterogeneity (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.00001). According to this systemic review, the expression of IL-8, TNF-a, MMP-9, and RAGE gene and protein was increased in pulp samples from teeth clinically diagnosed with irreversible symptomatic pulpitis.\n                  <\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1806_24","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:00:56Z","timestamp":1746849656000},"page":"S188-S190","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis"],"prefix":"10.4103","volume":"17","author":[{"given":"Aparna","family":"Rai","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloni","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, D. 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Patil Deemed to be University, School of Dentistry, Nerul, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhaj A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, MAK\u2019s Dental Solutions, Ghy, Guwahati, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Abbas","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics,Teerthanker Mahveer Dental College and Research Centre, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astha","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Subharti Dental College and Hospital, Uttar Pradesh, 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in dentinal fluid as an approach to molecular diagnostics in pulpitis","volume":"53","author":"Brizuela","year":"2020","journal-title":"Int Endod J"},{"key":"R13-20250513","doi-asserted-by":"crossref","first-page":"10395","DOI":"10.3390\/app112110395","article-title":"Biochemical mapping of the inflamed human dental pulp","volume":"11","author":"Kritikou","year":"2021","journal-title":"Appl Sci"},{"key":"R14-20250513","doi-asserted-by":"crossref","first-page":"e23782","DOI":"10.1097\/MD.0000000000023782","article-title":"Levels of matrix metalloproteinase-8 and cold test in reversible and irreversible pulpitis","volume":"99","author":"Aguirre-L\u00f3pez","year":"2020","journal-title":"Medicine (Baltimore)"}],"container-title":["Journal of Pharmacy and Bioallied 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