{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:54Z","timestamp":1787840454155,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mandibular reconstruction is a critical procedure in the management of defects caused by trauma, tumors, or congenital anomalies. Traditional methods often face challenges such as poor fit, extended surgery time, and postoperative complications. The advent of 3D printing technology allows for the precise fabrication of titanium implants tailored to individual anatomy. This study evaluates the clinical outcomes of using 3D-printed titanium implants in mandibular reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This prospective study involved 30 patients (mean age: 45 \u00b1 12 years) with mandibular defects requiring reconstruction. Customized 3D-printed titanium implants were designed using preoperative CT scans and fabricated using laser powder bed fusion technology. Surgical procedures included implant placement combined with soft tissue grafts where necessary. Follow-ups were conducted at 1, 3, 6, and 12 months postoperatively to assess implant stability, functional outcomes (mastication and speech), and aesthetic satisfaction. Data were analyzed using descriptive statistics and paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests for functional improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All patients successfully underwent implantation without intraoperative complications. At 12 months, the implant survival rate was 96.7%. Functional assessment showed a significant improvement in chewing efficiency (mean increase: 40%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and speech clarity (mean increase: 30%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Patient satisfaction regarding aesthetics was high, with 85% rating outcomes as excellent. Postoperative complications included mild infection in two patients (6.7%) and implant loosening in one patient (3.3%), all managed successfully.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>3D-printed titanium implants demonstrated excellent clinical efficacy and safety in mandibular reconstruction, offering significant functional and aesthetic benefits. The technology holds promise for personalized care in maxillofacial surgery, though long-term studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1816_24","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:01:50Z","timestamp":1750208510000},"page":"S1529-S1531","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of Using 3D-Printed Titanium Implants in Mandibular Reconstruction"],"prefix":"10.4103","volume":"17","author":[{"given":"Ban Ahmed","family":"Almudarris","sequence":"first","affiliation":[{"name":"Department of Restorative and Prosthodontic Unit, College of Dentistry, City University Ajman, Ajman, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmay","family":"Rajput","sequence":"additional","affiliation":[{"name":"Public Health-Immunization Team, MDRD, Halifax Infirmary Hospital, 1796 Sumer St, Halifax, NSB3H3A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virendra","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Government Medical College, Dungarpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaikh Mohammad Abdul","family":"Feroz","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahtesham Ahmad","family":"Qurishi","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Diagnostic Sciences, College of dentistry, Jizan University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, SGT University, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husham E.","family":"Homeida","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Diagnostic Sciences, College of dentistry, Jizan University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","first-page":"1958","article-title":"Application of 3D-printed titanium implants in mandibular defect reconstruction:A retrospective study","volume":"76","author":"Sun","year":"2018","journal-title":"J Oral Maxillofac Surg"},{"key":"R2-20250618","first-page":"1351","article-title":"Computer-aided design and computer-aided manufacturing in mandibular reconstruction with fibular free flap:A systematic review of literature","volume":"43","author":"Mazzoni","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"R3-20250618","first-page":"3125","article-title":"Titanium's role in reconstructive surgery:A comprehensive review","volume":"68","author":"Heller","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"R4-20250618","first-page":"1465","article-title":"Patient-specific 3D-printed titanium plates improve outcomes in mandibular reconstruction","volume":"49","author":"Li","year":"2020","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R5-20250618","first-page":"e0205155","article-title":"Use of 3D-printed titanium implants in oral and maxillofacial surgery:Clinical and laboratory analysis","volume":"13","author":"Tanaka","year":"2018","journal-title":"PLoS One"},{"key":"R6-20250618","first-page":"1422","article-title":"Accuracy of 3D-planned reconstructive surgery with prefabricated plates in head and neck oncology","volume":"44","author":"Schepers","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R7-20250618","article-title":"Materials Properties Handbook:Titanium Alloys","author":"Boyer","year":"2007","journal-title":"ASM International"},{"key":"R8-20250618","first-page":"432","article-title":"Long-term outcomes of 3D-printed titanium implants for mandibular reconstruction:A retrospective study","volume":"101","author":"Zhang","year":"2022","journal-title":"J Dent Res"},{"key":"R9-20250618","first-page":"731","article-title":"3D modeling, custom implants, and virtual surgery:Advances in mandibular reconstruction","volume":"37","author":"Parthasarathy","year":"2015","journal-title":"Head Neck"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1816_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:57Z","timestamp":1787836977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1816_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":9,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1816_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-12-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}