{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:24:02Z","timestamp":1787840642148,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Silver diamine fluoride (SDF) is a minimally invasive option for the arrest of early childhood caries (ECC). Its usage has been associated with significant reductions in caries progression, providing a cost-effective solution in pediatric dental care. This research aims to evaluate the efficacy of SDF compared to sodium fluoride varnish in arresting ECC in preschool children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This randomized controlled trial included 120 preschool children aged 2\u20135 years with diagnosed ECC. Participants were randomly assigned to receive either 38% SDF application or sodium fluoride varnish. The primary outcome was caries arrest rate, measured at 6 months. Secondary outcomes included parental satisfaction and child \u201coral health-related quality of life (OHRQoL)\u201d. Data analysis was performed using Chi-square and t-tests for comparison between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At the 6-month follow-up, children who received SDF treatment demonstrated a significantly higher caries arrest rate (85%) compared to those who received sodium fluoride varnish (50%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Parents reported higher satisfaction with the SDF treatment group, and improvements in OHRQoL were observed across both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SDF is a highly effectual treatment for arresting ECC in preschool children, offering a more efficacious option compared to traditional fluoride varnish treatments. Its application is well accepted by parents and positively impacts children\u2019s OHRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1843_24","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:00:10Z","timestamp":1750395610000},"page":"S2469-S2471","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Effectiveness of Silver Diamine Fluoride in Arresting Early Childhood Caries: A Prospective Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Anjumoni","family":"Daimary","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Rupnagar, Guwahati, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnish K.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Kalinga Institute of Dental Sciences, Campus 5, KIIT University, Patia, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda F.","family":"Mirza","sequence":"additional","affiliation":[{"name":"Pediatric Dentist Consultant, King Abdullah Medical Complex, Ministry of Health, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab","family":"Musalli","sequence":"additional","affiliation":[{"name":"King Abdulaziz Medical City, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renie K.","family":"Dewi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin, Kalimantan Selatan, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikala","family":"Bhandary","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, AB Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M.","family":"Khan","sequence":"additional","affiliation":[{"name":"Ministry of Health, Taif, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj K.","family":"Dangi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, RKDF Dental College and Research Centre, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"R1-20250930","first-page":"202","article-title":"Effectiveness of silver diamine fluoride in arresting early childhood caries:A randomised controlled clinical trial","volume":"25","author":"ElGhandour","year":"2024","journal-title":"Eur J Paediatr Dent"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"101751","DOI":"10.1016\/j.jebdp.2022.101751","article-title":"Changes in parental satisfaction and oral health-related quality of life after receiving atraumatic restorative treatment with or without SDF","volume":"22","author":"Jiang","year":"2022","journal-title":"J Evid Based Dent Pract"},{"key":"R3-20250930","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/jisppd.jisppd_34_21","article-title":"Evaluation of the clinical efficacy of 38% silver diamine fluoride in arresting dental caries in primary teeth","volume":"39","author":"Chaurasiya","year":"2021","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"R4-20250930","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1186\/s12903-023-03456-3","article-title":"Effectiveness of silver diamine fluoride versus sodium fluoride varnish in arresting ECC:A randomized clinical trial","volume":"23","author":"Yassin","year":"2023","journal-title":"BMC Oral Health"},{"key":"R5-20250930","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13063-020-4088-7","article-title":"Preventing early childhood caries with silver diamine fluoride:Study protocol for a randomised clinical trial","volume":"21","author":"Gao","year":"2020","journal-title":"Trials"},{"key":"R6-20250930","doi-asserted-by":"crossref","first-page":"104878","DOI":"10.1016\/j.jdent.2024.104878","article-title":"Effect of silver diamine fluoride on oral health-related quality of life of children with ECC","volume":"142","author":"Quritum","year":"2024","journal-title":"J Dent"},{"key":"R7-20250930","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1186\/s12903-023-03597-5","article-title":"Silver diamine fluoride versus sodium fluoride varnish in arresting ECC","volume":"23","author":"Abdellatif","year":"2023","journal-title":"BMC Oral Health"},{"key":"R8-20250930","doi-asserted-by":"crossref","first-page":"103522","DOI":"10.1016\/j.jdent.2020.103522","article-title":"Arresting early childhood caries using silver and fluoride products-A randomised trial","volume":"103","author":"Gao","year":"2020","journal-title":"J Dent"},{"key":"R9-20250930","doi-asserted-by":"crossref","first-page":"103375","DOI":"10.1016\/j.jdent.2020.103375","article-title":"A randomized clinical trial to arrest dentin caries in young children using silver diamine fluoride","volume":"99","author":"Mabangkhru","year":"2020","journal-title":"J Dent"},{"key":"R10-20250930","doi-asserted-by":"crossref","first-page":"217","DOI":"10.17219\/dmp\/143547","article-title":"Comparison of the effectiveness of 38% silver diamine fluoride and atraumatic restorative treatment for treating dental caries","volume":"59","author":"Satyarup","year":"2022","journal-title":"Dent Med Probl"},{"key":"R11-20250930","first-page":"3697","article-title":"Role of saliva in conservative dentistry","volume":"14","author":"Shetty","year":"2022","journal-title":"Int J Early Child Spec Educ"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1843_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:24Z","timestamp":1787837184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1843_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":11,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1843_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"assertion":[{"value":"2024-12-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}