{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:51:08Z","timestamp":1791341468552,"version":"4.3.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    An increasing number of systemic inflammatory diseases, such as diabetes mellitus, rheumatoid arthritis (RA), cardiovascular disease, and respiratory disorders, have been linked to periodontitis, a chronic inflammatory condition of the gums. This review delves into the complex connections between systemic inflammatory multimorbidity and periodontitis, emphasizing how these illnesses are exacerbated by chronic inflammation and sharing similar pathophysiological pathways. Common inflammatory pathways that involve periodontal pathogens, like\n                    <jats:italic toggle=\"yes\">Porphyromonas gingivalis<\/jats:italic>\n                    , and important cytokines, like TNF-\u03b1, IL-1\u03b2, and IL-6, drive the bidirectional link between periodontitis and systemic illnesses. These elements play a part in the systemic spread of inflammation, which has a negative impact on distant organs and tissues. Since treating periodontitis may enhance general health outcomes and lessen the burden of systemic disorders, the review highlights the necessity of an integrated healthcare approach that takes dental and systemic health into account. Healthcare professionals can significantly lessen the effects of systemic inflammatory multimorbidity by treating periodontitis with efficient dental treatment and patient education, thereby improving patient well-being and quality of life.\n                  <\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1855_24","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:00:10Z","timestamp":1750395610000},"page":"S2067-S2070","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Periodontitis and Systemic Inflammatory Multimorbidity: Narrative Review of Literature"],"prefix":"10.4103","volume":"17","author":[{"given":"Mohammad","family":"Almagbol","sequence":"first","affiliation":[{"name":"Department of Community and Periodontics, Faculty of Dentistry, King Khalid University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"R1-20250930","first-page":"835","article-title":"American Academy of Periodontology Task Force","volume":"86","year":"2015","journal-title":"J Periodontol"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4103\/0972-124X.106878","article-title":"Periodontitis and systemic diseases:A literature review","volume":"16","author":"Arigbede","year":"2012","journal-title":"J Indian Soc Periodontol"},{"key":"R3-20250930","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3390\/medicina56060272","article-title":"Periodontitis, low-grade inflammation and systemic health:A scoping review","volume":"56","author":"Cecoro","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"R4-20250930","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1902\/jop.2006.060010","article-title":"Systematic review of the association between respiratory diseases and oral health","volume":"77","author":"Azarpazhooh","year":"2006","journal-title":"J Periodontol"},{"key":"R5-20250930","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.joen.2016.07.007","article-title":"Influence of periodontal disease on systemic diseases:A narrative review","volume":"42","author":"Khalighinejad","year":"2016","journal-title":"J Endod"},{"key":"R6-20250930","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/00325481.2018.1396876","article-title":"Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases","volume":"130","author":"Cardoso","year":"2018","journal-title":"Postgrad Med"},{"key":"R7-20250930","first-page":"31","article-title":"Are periodontal diseases risk factors for certain systemic disorders\u2013what matters to medical practitioners?","volume":"9","author":"Jin","year":"2003","journal-title":"Hong Kong Med J"},{"key":"R8-20250930","first-page":"441","article-title":"Role of systemic inflammation and oxidative stress in the link between periodontitis and systemic diseases","volume":"19","author":"Meurman","year":"2021","journal-title":"Oral Health Prev Dent"},{"key":"R9-20250930","first-page":"443","article-title":"Periodontal disease as a risk factor for various systemic diseases","volume":"40","author":"Kaur","year":"2013","journal-title":"J Clin Periodontol"},{"key":"R10-20250930","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1902\/annals.1998.3.1.108","article-title":"The role of inflammatory mediators in the pathogenesis of periodontal disease","volume":"3","author":"Page","year":"1998","journal-title":"Ann Periodontol"},{"key":"R11-20250930","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"R12-20250930","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Immuno-inflammatory pathogenesis of periodontitis:Implications for novel therapeutic approaches","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"R13-20250930","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/jcpe.12247","article-title":"The association between periodontitis and coronary heart disease:A clinical study","volume":"41","author":"Zhou","year":"2014","journal-title":"J Clin Periodontol"},{"key":"R14-20250930","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1902\/annals.2003.8.1.54","article-title":"Periodontal disease as a risk factor for adverse pregnancy outcomes","volume":"8","author":"Scannapieco","year":"2003","journal-title":"Ann Periodontol"},{"key":"R15-20250930","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1111\/jcpe.12088","article-title":"Infection and inflammatory mechanisms","volume":"40","author":"Van Dyke","year":"2013","journal-title":"J Clin Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1855_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:24Z","timestamp":1787837184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1855_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":15,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1855_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"assertion":[{"value":"2024-12-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}