{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:52Z","timestamp":1787775832544,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Infertility is considered a global concern, significantly contributing to females with PCOS. This case study describes the journey of a 33-year-old woman with PCOS and her 35-year-old male partner, who had been trying to conceive for over four years. They also had a history of failed intrauterine insemination (IUI) and intracytoplasmic sperm injection (ICSI) cycles despite normal semen parameters of the male partner, the female investigations revealed abnormalities in hormonal luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that were the identified contributing factors. Further, the couple underwent significant counseling emphasizing lifestyle changes to manage infertility caused by polycystic ovarian syndrome (PCOS). Following ovarian stimulations for oocyte retrieval, 17 oocytes were retrieved, and eight were of Metaphase II. Six zygotes formed after performing an ICSI. They expanded into blastocysts, and further blastocysts underwent cryopreservation. Later, with progesterone support, the frozen embryo transfer was performed, resulting in a successful pregnancy. After embryo transfer, the female patients underwent regular follow-ups to monitor the possible complications of pregnancy. This case report demonstrates the potential challenges and success of ART employing PCOS patients, despite previously unsuccessful IUI and ICSI attempts and the presence of hormonal imbalances. The utilization of controlled ovarian stimulation, ICSI, FET, and lifestyle modifications worked effectively to achieve positive outcomes in pregnancy. The case study highlights the significance of individualized treatments and guidance in managing infertility caused by PCOS. The significance of routine follow-ups in ensuring the health of both the mother and the fetus, that shows PCOS patients, can have successful reproductive outcomes.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_1916_24","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T14:00:14Z","timestamp":1744207214000},"page":"S964-S967","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Case Report on Managing PCOS-Related Infertility: Successful Pregnancy Achieved via Controlled Ovarian Stimulation and Intracytoplasmic Sperm Injection (ICSI)"],"prefix":"10.4103","volume":"17","author":[{"given":"Princee","family":"Tyagi","sequence":"first","affiliation":[{"name":"Department of Clinical Embryology, School of Allied Health Science, Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"More","sequence":"additional","affiliation":[{"name":"Department of Clinical Embryology, School of Allied Health Science, Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namarata","family":"Anjankar","sequence":"additional","affiliation":[{"name":"Department of Clinical Embryology, School of Allied Health Science, Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shradha","family":"Ulhe","sequence":"additional","affiliation":[{"name":"Department of Clinical Embryology, School of Allied Health Science, Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"716","DOI":"10.12688\/f1000research.136619.1","article-title":"Case report: Effect of intraovarian platelet-rich plasma therapy on latent female genital tuberculosis patient","volume":"12","author":"Dutta","year":"2023","journal-title":"F1000Res"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and management of infertility: A review","volume":"326","author":"Carson","year":"2021","journal-title":"JAMA"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2018.04.008","article-title":"Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy","volume":"182","author":"Patel","year":"2018","journal-title":"J Steroid Biochem Mol Biol"},{"key":"R4-20250513","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2147\/TACG.S200341","article-title":"Genetic basis of polycystic ovary syndrome (PCOS): Current perspectives","volume":"12","author":"Khan","year":"2019","journal-title":"Appl Clin Genet"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1055\/s-2008-1042958","article-title":"Oocyte quality in adult polycystic ovary syndrome","volume":"26","author":"Patel","year":"2008","journal-title":"Semin Reprod Med"},{"key":"R6-20250513","doi-asserted-by":"crossref","first-page":"e12487","DOI":"10.1002\/rmb2.12487","article-title":"Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research","volume":"21","author":"Harada","year":"2022","journal-title":"Reprod Med Biol"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12958-023-01118-1","article-title":"Risk factors for low oocyte retrieval in patients with polycystic ovarian syndrome undergoing in vitro fertilization","volume":"21","author":"Jin","year":"2023","journal-title":"Reprod Biol Endocrinol"},{"key":"R8-20250513","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"(Suppl 1)","key":"R9-20250513","first-page":"48","article-title":"Can we harvest more mature oocytes by repeating gonadotropin-releasing hormone agonist doses in polycystic ovarian syndrome patients at risk of OHSS in antagonist cycles? 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