{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:24:30Z","timestamp":1787772270699,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Chronic periodontitis is a prevalent inflammatory condition affecting the supporting structures of teeth. Adjunctive therapies to scaling and root planing (SRP) play a crucial role in enhancing treatment outcomes. This study aimed to compare the clinical effectiveness of subgingivally delivered 0.5% azithromycin gel and 1% chlorhexidine gel as adjuncts to SRP in the management of chronic periodontitis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A comparative clinical evaluation was conducted involving 60 participants diagnosed with chronic periodontitis. They were randomly assigned to two groups: Group A received subgingival application of 0.5% azithromycin gel after SRP, whereas Group B received 1% chlorhexidine gel in a similar manner. Clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL), and gingival index (GI) were recorded at baseline and 3-month follow-up.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Both groups demonstrated significant improvements in clinical parameters after treatment. However, Group A exhibited a greater reduction in PPD (mean decrease of 2.5 mm) compared with Group B (mean decrease of 1.8 mm). Similarly, Group A showed a higher gain in CAL (mean gain of 2.3 mm) compared with Group B (mean gain of 1.5 mm). In addition, a significant reduction in GI was observed in both groups, with Group A showing slightly better outcomes.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Subgingivally delivered 0.5% azithromycin gel demonstrated superior clinical efficacy as an adjunct to SRP in the treatment of chronic periodontitis compared with 1% chlorhexidine gel. The findings suggest that azithromycin gel may serve as a promising therapeutic option in managing periodontal disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_193_24","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T13:00:14Z","timestamp":1716296414000},"page":"S2250-S2252","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Comparative Clinical Evaluation of Subgingivally Delivered 0.5% Azithromycin Gel and 1% Chlorhexidine Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis"],"prefix":"10.4103","volume":"16","author":[{"given":"Priyanka","family":"Vhanmane","sequence":"first","affiliation":[{"name":"Department of Periodontology, Bharati Vidyapeeth (Deemed to be University), Pune, Dental College and Hospital, Sangli, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Nandy","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Bharati Vidyapeeth (Deemed to be University), Pune, Dental College and Hospital, Sangli, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin B.","family":"Mangalekar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Bharati Vidyapeeth (Deemed to be University), Pune, Dental College and Hospital, Sangli, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeeth","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Bharati Vidyapeeth (Deemed to be University), Pune, Dental College and Hospital, Sangli, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta V.","family":"Sagare","sequence":"additional","affiliation":[{"name":"Department of Conservative and Endodontics, Bharati Vidyapeeth (Deemed to be University), Pune, Dental College and Hospital, Sangli, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Kumbhare","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Bharati Vidyapeeth (Deemed to be University), Pune, Dental College and Hospital, Sangli, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1902\/annals.1999.4.1.32","article-title":"Periodontics","volume":"4","author":"Flemmig","year":"1994","journal-title":"Ann Periodontol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1902\/jop.2012.110558","article-title":"Effect of gingivitis on Azithromycin concentrations in gingival crevicular fluid","volume":"83","author":"Jain","year":"2012","journal-title":"J Periodontol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1834-7819.2009.01146.x","article-title":"Non-surgical management of periodontal disease","volume":"54","author":"Darby","year":"2009","journal-title":"Aust Dent J"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1034\/j.1601-0825.9.s1.6.x","article-title":"Microbial shifts after subgingival debridement and formation of bacterial resistance when combined with local or systemic antimicrobials","volume":"9","author":"Quirynen","year":"2003","journal-title":"Oral Dis"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1034\/j.1600-051x.2000.027009648.x","article-title":"Comparison of the microbiota of supra- and subgingival plaque in health and periodontitis","volume":"27","author":"Xim\u00e9nez-Fyvie","year":"2000","journal-title":"J Clin Periodontol"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1034\/j.1600-0757.2001.22250106.x","article-title":"Nonsurgical periodontal therapy","volume":"25","author":"Drisko","year":"2001","journal-title":"Periodontol 2000"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1902\/annals.2003.8.1.115","article-title":"Systemic anti-infective periodontal therapy. A systematic review","volume":"8","author":"Haffajee","year":"2003","journal-title":"Ann Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_193_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:35:37Z","timestamp":1787769337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_193_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":7,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_193_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]},"assertion":[{"value":"2024-03-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}