{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:31:41Z","timestamp":1787776301304,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Proton pump inhibitors (PPIs) are the most commonly used drug worldwide. PPIs are benzimidazole derivatives and are basic in nature; therefore, they are dispensed in enteric-coated tablets or capsules to avoid degradation from gastric acid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Study to establish the relationship between omeprazole (PPI) and acute interstitial nephritis (AIN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To find the effect of PPI alone, PPI with diclofenac, PPI with ofloxacin on renal function tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In the present study, we are analyzing PPI (omeprazole) as a main group. The group is again divided into three subgroups containing six rats in each. The relation between PPI and AIN is observed by the administration of PPI alone. To find this relation, we combine the PPI with nonsteroidal anti-inflammatory drug (NSAID) diclofenac and the antimicrobial agent ofloxacin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Omeprazole 20 mg\/kg\/day alone showed a statistically significant difference in serum creatinine and blood urea values. Omeprazole 20 mg\/kg\/day and ofloxacin 60 mg\/kg\/day did not show a statistically significant difference in serum creatinine and blood urea values. Omeprazole 20 mg\/kg\/day and diclofenac showed statistically significant difference in serum creatinine and blood urea values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>With longer administration of PPIs, it did produce derangement of renal function tests (RFTs), and with concurrent administration of drugs like ofloxacin and diclofenac, it hastened the process of renal damage as indicated by deranged RFTs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1964_24","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T03:00:57Z","timestamp":1741662057000},"page":"S381-S383","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Study to Establish the Relationship between Omeprazole (PPI) and Acute Interstitial Nephritis (AIN)"],"prefix":"10.4103","volume":"17","author":[{"given":"Bite","family":"Bapurao","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swanand","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit Sidram","family":"Ambad","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, JNMC, DMIHER, Sawangi, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"R1-20250513","first-page":"273","article-title":"Proton pump inhibitors:An update","volume":"6","author":"Bruce","year":"2002","journal-title":"Am Fam Physician"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.1365-2125.1998.00791.x","article-title":"Compliance with restrictions on the subsidized use of proton pump inhibitors in Australia","volume":"46","author":"McManus","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cgh.2005.11.004","article-title":"Proton pump inhibitors and acute interstitial nephritis","volume":"4","author":"Geevasinga","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R4-20250513"},{"key":"R5-20250513","first-page":"8","article-title":"Proton pump inhibitors:When is enough, enough?","journal-title":"Brit J Pharmacol"},{"key":"R6-20250513","first-page":"1553","article-title":"Trends in prescribing gastroprotective agents with non-steroidal anti-inflammatory drugs in an orthopedic outpatient unit of a tertiary care hospital","volume":"3","author":"Raghvendra","year":"2009","journal-title":"J Clin Daog Res"},{"key":"R7-20250513","first-page":"37","article-title":"Use of proton pump inhibitors ingeneral practice. Is it rationale?","volume":"3","author":"Nouseen","year":"2014","journal-title":"Int J Med Res Health Sci"},{"key":"R8-20250513","doi-asserted-by":"crossref","first-page":"973578","DOI":"10.1155\/2014\/973578","article-title":"Drug utilization study in medical emergency unit of a tertiary care hospital in north India","volume":"2014","author":"Kaur","year":"2014","journal-title":"Emerg Med Int"},{"key":"R9-20250513","first-page":"e49883","article-title":"Impact of Proton Pump Inhibitors on Kidney Function and Chronic Kidney Disease Progression:A Systematic Review","volume":"15","author":"Parmar","year":"2023","journal-title":"Cureus"},{"key":"R10-20250513","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/0976-0105.121650","article-title":"Drug utilization in emergency medicine department at a tertiary care hospital:A prospective study","volume":"4","author":"Barot","year":"2013","journal-title":"J Basic Clin Pharmacy"},{"key":"R11-20250513","first-page":"278","article-title":"Study of rational prescribing and dispensing of preparations with nonsteroidal anti-inflammatory drugs in orthopedic outpatient department","volume":"4","author":"Pravinkumar","year":"2015","journal-title":"Asian J Pharm Clin Res"},{"key":"R12-20250513","first-page":"482","article-title":"Study on drug utilization pattern of chronic renal failure patient in a tertiary care hospital","volume":"6","author":"Tamilselvan","year":"2014","journal-title":"Int J Pharm Sci"},{"key":"R13-20250513","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5530\/ijopp.7.4.2","article-title":"Prospective assessment of prescribing pattern of intravenous proton pump inhibitors in an Indian tertiary care teaching hospital","volume":"7","author":"Churi","year":"2004","journal-title":"Indian J Pharmacy Pract"},{"key":"R14-20250513","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.18203\/2319-2003.ijbcp20162220","article-title":"Proton pump inhibitors:Are they safe on kidneys:A histopathological study","volume":"5","author":"Limaye","year":"2016","journal-title":"Int J Basic Clin Pharmacol"},{"key":"R15-20250513","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biomedicines12071414","article-title":"Association between proton pump inhibitor use and risk of incident chronic kidney disease:Systematic review and meta-analysis","volume":"12","author":"Ang","year":"2024","journal-title":"Biomedicines"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1964_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:07:54Z","timestamp":1787774874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_1964_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":15,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_1964_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"2024-12-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}