{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:18Z","timestamp":1787840358638,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by hyperandrogenism, insulin resistance, and dyslipidemia. Inflammation and oxidative stress play critical roles in its pathogenesis. This observational cross-sectional study evaluated the relationship between serum Caspase-1, interleukin-10 (IL-10), homeostatic model assessment of insulin resistance (HOMA-IR), free androgen index (FAI), lipid profiles, and oxidative stress markers in women with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 150 women diagnosed with PCOS participated in this study. Serum levels of Caspase-1, IL-10, HOMA-IR, FAI, lipid profiles (total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides), malondialdehyde (MDA), and superoxide dismutase (SOD) were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results revealed significant elevations in Caspase-1, HOMA-IR, and lipid profiles, while IL-10 levels were lower compared to normal populations. Additionally, oxidative stress markers, including MDA, were significantly increased, while SOD levels showed a decline. Positive correlations were observed between Caspase-1, HOMA-IR, dyslipidemia, and oxidative stress markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest a crucial link between inflammation, insulin resistance, and oxidative stress in PCOS, contributing to its complex pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_1994_24","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:00:09Z","timestamp":1740200409000},"page":"S369-S371","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome"],"prefix":"10.4103","volume":"17","author":[{"given":"Neelam","family":"Gusain","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Nehru Medical College, DMIHER (DU), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Anjankar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Nehru Medical College, DMIHER (DU), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Ambad","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Nehru Medical College, DMIHER (DU), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The Androgen Excess 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