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By using qRT-PCR, we discovered that fibroblast growth factor receptor-5 (FGFR5) was 4.2-fold more highly expressed in non-regeneration lesions compared to intact control and regenerating animals. Furthermore, in cultured dorsal root ganglion neurons (DRGN), short interfering RNA (siRNA)-mediated knockdown of FGFR5 had no effect on DRGN neurite outgrowth, indicating that the gene\u2019s suppression has no effect on axon regeneration and may play other roles in the CNS besides axon regeneration.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_199_23","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T02:07:37Z","timestamp":1689127657000},"page":"S1111-S1115","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Suppression of Fibroblast Growth Factor Receptor-5 (FGFR5) has no Impact on Axon Regeneration after SCI"],"prefix":"10.4103","volume":"15","author":[{"given":"Sharif","family":"Alhajlah","sequence":"first","affiliation":[{"name":"Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia"},{"name":"Neuroscience and 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