{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:35Z","timestamp":1787840435038,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The increasing prevalence of denture-associated infections highlights the need for innovative materials with intrinsic antimicrobial properties. Novel self-disinfecting denture base materials incorporating antimicrobial agents offer a promising solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Three groups of denture base materials were tested: Group A (conventional polymethyl methacrylate, PMMA), Group B (PMMA infused with silver nanoparticles), and Group C (PMMA infused with chlorhexidine microspheres). Samples (n = 10\/group) were fabricated according to standardized protocols. Antimicrobial efficacy was assessed against\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                      using a disc diffusion assay and a biofilm inhibition test. Zone of inhibition (ZOI) and colony-forming unit (CFU) counts were measured after 24 and 48 hours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Group A showed no significant antimicrobial activity, with ZOI values of 0 mm for both pathogens. Group B exhibited moderate efficacy, with mean ZOI values of 10.5 \u00b1 1.2 mm and 8.8 \u00b1 1.0 mm against\n                      <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      , respectively. Group C demonstrated the highest antimicrobial activity, with mean ZOI values of 15.3 \u00b1 1.5 mm and 13.7 \u00b1 1.3 mm. Biofilm inhibition was significantly higher in Group C (75%) compared with Group B (50%) and Group A (10%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Novel self-disinfecting denture base materials infused with antimicrobial agents, particularly chlorhexidine microspheres, exhibit superior antimicrobial efficacy compared with conventional PMMA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_220_25","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:00:56Z","timestamp":1750208456000},"page":"S1659-S1661","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Efficacy of Novel Self-Disinfecting Denture Base Materials"],"prefix":"10.4103","volume":"17","author":[{"given":"Shubham","family":"Bhuktar","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Crown and Bridge, Dr. RRK Dental College Akola, Akola, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Hitech Dental College, Institute of Dental Science S\u201do\u201d A University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, National Dental, College and Hospital, Derabassi, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Oral Implantology, Dr. D.Y. Patil Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulbir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Prosthodontic and Crown & Bridge, Geetanjali Dental and Research Institute, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Prosthodontic and Crown & Bridge, Geetanjali Dental and Research Institute, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","first-page":"352","article-title":"Biofilm formation by Candida albicans and its relevance to oral candidosis:A review","volume":"83","author":"Ramage","year":"2004","journal-title":"Dent Res"},{"key":"R2-20250618","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1365-2842.2007.01753.x","article-title":"Effect of mechanical and chemical methods on denture biofilm accumulation","volume":"34","author":"Paranhos","year":"2007","journal-title":"J Oral Rehabil"},{"key":"R3-20250618","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biotechadv.2008.09.002","article-title":"Silver nanoparticles as a new generation of antimicrobials","volume":"27","author":"Rai","year":"2009","journal-title":"Biotechnol Adv"},{"key":"R4-20250618","first-page":"387","article-title":"Antifungal activity of silver nanoparticles and their effect on adherence to denture acrylic resin","volume":"174","author":"Monteiro","year":"2012","journal-title":"Mycopathologia"},{"key":"R5-20250618","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.msec.2018.05.069","article-title":"An overview of application of silver nanoparticles for biomaterials in dentistry","volume":"91","author":"Bapat","year":"2018","journal-title":"Mater Sci Eng C"},{"key":"R6-20250618","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1574-6976.2011.00278.x","article-title":"Candida glabrata, Candida parapsilosis and Candida tropicalis:Biology, epidemiology, pathogenicity and antifungal resistance","volume":"36","author":"Silva","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"R7-20250618","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0109-5641(02)00102-1","article-title":"Antibacterial properties of resin composites and dentin bonding systems","volume":"19","author":"Imazato","year":"2003","journal-title":"Dent Mater"},{"key":"R8-20250618","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/0972-124X.107466","article-title":"Biofilm and dental implant:The microbial link","volume":"17","author":"Dhir","year":"2013","journal-title":"J Indian Soc Periodontol"},{"key":"R9-20250618","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1365-2591.2008.01540.x","article-title":"The properties and applications of chlorhexidine in endodontics","volume":"42","author":"Mohammadi","year":"2009","journal-title":"Int Endod J"},{"key":"R10-20250618","first-page":"e65","article-title":"Surface properties and biofilm formation on restorative resins","volume":"31","author":"Cazzaniga","year":"2015","journal-title":"Dent Mater"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_220_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:43Z","timestamp":1787836963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_220_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":10,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_220_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}