{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:21:34Z","timestamp":1787840494958,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Periodontitis is a persistent inflammatory condition resulting in tooth loss. Mechanical treatment alone may inadequately eradicate microorganisms from pockets, necessitating the additional local injection of pharmaceuticals. Pomegranate has strong antibacterial, antiviral, antioxidant, anti-inflammatory, wound healing, and probiotic effects.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n To evaluate the efficacy of locally delivered pomegranate gel when used as an adjunct to scaling and root planning (SRP) in the treatment of chronic periodontitis (CP).<\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n A total of 20 patients contributing 120 sites randomly received one of the three treatment protocols and resultant clinical parameters were assessed at baseline, 3 months, and 6 months.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n All three treatment modalities resulted in significant improvement in all clinical parameters with the greatest improvement in probing pocket depth (PPD) and relative attachment level (RAL) noted in Group 3.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Local application of 5%-pomegranate gel after SRP is effective in CP patients and hence can be recommended as an adjunctive non-surgical treatment option.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_223_25","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:01:14Z","timestamp":1750208474000},"page":"S1356-S1358","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Punica granatum: An Adjunct in the Non-Surgical Management of Chronic Periodontitis"],"prefix":"10.4103","volume":"17","author":[{"given":"Alina","family":"Pauly","sequence":"first","affiliation":[{"name":"Department of Periodontology, RajaRajeswari Dental College and Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Vinaya","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, RajaRajeswari Dental College and Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimmi","family":"Janardhanan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, RajaRajeswari Dental College and Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeba","family":"Sadaf","sequence":"additional","affiliation":[{"name":"Department of Periodontology, RajaRajeswari Dental College and Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Shaji","sequence":"additional","affiliation":[{"name":"Department of Periodontology, RajaRajeswari Dental College and Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","first-page":"12","article-title":"The effect of punica granatum gel as an adjunctive therapy in patients with chronic periodontitis: A clinical, microbiological and histological study","volume":"15","author":"Dobayan","year":"2019","journal-title":"J Am Sci"},{"key":"R2-20250618","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.4103\/jpbs.JPBS_101_17","article-title":"Ancient seed for modern cure \u2013pomegranate review of therapeutic applications in periodontics","volume":"9","author":"Thangavelu","year":"2017","journal-title":"J Pharm Bioall Sci"},{"key":"R3-20250618","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/prd.12121","article-title":"Antibiotics\/antimicrobials: Systemic and local administration in the therapy of mild to moderately advanced periodontitis","volume":"71","author":"Jepsen","year":"2016","journal-title":"Periodontol 2000"},{"key":"R4-20250618","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4103\/0972-124X.138678","article-title":"Punica granatum: A review on its potential role in treating periodontal disease","volume":"18","author":"Prasad","year":"2014","journal-title":"J Indian Soc Periodontol"},{"key":"R5-20250618","first-page":"70","article-title":"Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy","volume":"7","author":"Sastravaha","year":"2005","journal-title":"J Int Acad Periodontol"},{"key":"R6-20250618","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1902\/jop.2009.080510","article-title":"Relationship between intake of green tea and periodontal disease","volume":"80","author":"Kushiyama","year":"2009","journal-title":"J Periodontol"},{"key":"R7-20250618","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/2279-042X.137076","article-title":"Efficacy of a local-drug delivery gel containing extracts of Quercus brantii and Coriandrum sativum as an adjunct to scaling and root planing in moderate chronic periodontitis patients","volume":"3","author":"Yaghini","year":"2014","journal-title":"J Res Pharm Pract"},{"key":"R8-20250618","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3126\/kumj.v18i3.49224","article-title":"Clinical efficacy of subgingivally delivered punica granatum chip and gel in management of chronic periodontitis patients","volume":"18","author":"Tyagi","year":"2020","journal-title":"Kathmandu Univ Med J"},{"key":"R9-20250618","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/jisp.jisp_243_20","article-title":"A comparison of the efficacy of scaling and root planning with application of pomegranate chip, pomegranate gel, and scaling and root planing in sufferers with adult periodontitis \u2013 A prospective study","volume":"25","author":"Tyagi","year":"2021","journal-title":"J Indian Soc Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_223_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:23:57Z","timestamp":1787837037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_223_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":9,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_223_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}