{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:35Z","timestamp":1787840435068,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Chronic periodontitis is a common inflammatory condition that is worsened in smokers owing to the harmful impact of smoking on periodontal tissues. Curcumin gel has shown promise as a local medication delivery method owing to its anti-inflammatory, antioxidant, and antibacterial effects.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A randomized clinical study was performed on 40 smokers diagnosed with chronic periodontitis. Participants were categorized into two groups: Group A (n = 20) had scale and root planing (SRP) only, while Group B (n = 20) got SRP in conjunction with curcumin gel as a local medication delivery supplement. Clinical measures, including as probing pocket depth (PPD), clinical attachment level (CAL), and gingival index (GI), were evaluated at baseline, 4 weeks, and 8 weeks. Curcumin gel was administered in periodontal pockets with probing pocket depth (PPD) \u22655 mm in patients of Group B.<\/jats:p>\n <\/jats:sec>\n \n Outcomes:<\/jats:title>\n \n At 8 weeks, Group B exhibited a significant decrease in PPD (mean reduction: 3.5 mm) compared to Group A (mean reduction: 2.0 mm). The improvement in clinical attachment level (CAL) was more pronounced in Group B (mean gain: 2.8 mm) compared to Group A (mean gain: 1.5 mm). Group B had a substantial drop in GI scores (mean reduction: 1.2) vs to Group A (mean reduction: 0.8). The supplementary use of curcumin gel led to statistically significant improvements in all clinical indicators (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Curcumin gel as a localized medication delivery adjunct significantly improves the clinical results of scaling and root planing in the treatment of chronic periodontitis in smokers.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_255_25","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:00:59Z","timestamp":1750208459000},"page":"S1683-S1685","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Shruti","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G","family":"Jyothi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anishka","family":"Dhanai","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemlata","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utkarsh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1902\/jop.2004.75.2.196","article-title":"Cigarette smoking and the periodontal patient","volume":"75","author":"Johnson","year":"2004","journal-title":"J Periodontol"},{"issue":"(Suppl 1)","key":"R2-20250618","first-page":"S44","article-title":"Smoking and periodontal diseases","volume":"54","author":"Heitz-Mayfield","year":"2009","journal-title":"Aust Dent J"},{"key":"R3-20250618","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1902\/jop.2000.71.5.743","article-title":"Smoking-attributable periodontitis in the United States: Findings from NHANES III","volume":"71","author":"Tomar","year":"2000","journal-title":"J Periodontol"},{"key":"R4-20250618","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: Lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J"},{"key":"R5-20250618","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti-inflammatory effects of curcumin in the inflammatory diseases: status, limitations and countermeasures","volume":"15","author":"Peng","year":"2021","journal-title":"Drug Des Devel Ther"},{"issue":"(Suppl 11)","key":"R6-20250618","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-051X.2010.01671.x","article-title":"How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis?","volume":"38","author":"Preshaw","year":"2011","journal-title":"J Clin Periodontol"},{"key":"R7-20250618","first-page":"1783","article-title":"Curcumin and its potential role in periodontal therapy: A review","volume":"10","author":"Jayakumar","year":"2019","journal-title":"Int J Pharm Sci Res"},{"key":"R8-20250618","first-page":"470","article-title":"Evaluation of the efficacy of curcumin as a local drug delivery system in chronic periodontitis patients: A clinical study","volume":"17","author":"Gupta","year":"2013","journal-title":"J Indian Soc Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_255_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:44Z","timestamp":1787836964000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_255_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":8,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_255_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}