{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:48Z","timestamp":1787775888640,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Repeated implantation failure (RIF) is a significant challenge in IVF treatment, often related to insufficient endometrial thickness and poor embryo-endometrium synchrony. Platelet-rich plasma (PRP) therapy has shown promise in various medical fields but is under-explored in gynecology. This study aims to evaluate the effectiveness of PRP therapy in improving endometrial thickness and enhancing embryo-endometrium synchrony in women with RIF undergoing IVF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The primary objective is to assess whether PRP therapy improves pregnancy outcomes, endometrial thickness, and embryo implantation rates in women with repeated implantation failure. Secondary objectives include comparing PRP therapy\u2019s effectiveness to traditional IVF without PRP and establishing a standardized protocol for PRP preparation in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>\n                      This prospective, randomized, controlled trial involved 100 women with a history of repeated implantation failure and thin endometrium. Participants were randomly assigned to two groups: an intervention group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 50) receiving autologous PRP therapy and a control group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 50) receiving IVF without PRP. PRP was prepared using a two-step centrifugation process. Endometrial thickness, embryo implantation rates, and pregnancy outcomes were compared between the two groups. Statistical analysis was performed using SPSS or R, with descriptive statistics, Chi-square tests, and t-tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Expected Results:<\/jats:title>\n                    <jats:p>It is anticipated that the PRP therapy group will exhibit improved endometrial thickness, higher embryo implantation rates, and better pregnancy outcomes compared to the control group. Additionally, successful embryo transfers and live birth rates are expected to increase in the PRP-treated group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Implications:<\/jats:title>\n                    <jats:p>This study could provide valuable insights into the role of PRP therapy in enhancing IVF success rates for women with RIF, potentially offering a novel therapeutic approach in fertility treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_260_25","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T09:00:14Z","timestamp":1745226014000},"page":"S897-S900","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Study Protocol: Evaluating the Effect of Autologous Platelet-Rich Plasma Infusion in the Endometrial Cavity for Enhanced Embryo-Endometrium Synchrony in Patients with Repeated Implantation Failure"],"prefix":"10.4103","volume":"17","author":[{"given":"Sanket","family":"Mahajan","sequence":"first","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"More","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Anjankar","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Consultant and Director, Varma Test Tube Baby and IVF Centre, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Nawale","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"R1-20250513","first-page":"442","article-title":"Platelet-rich plasma as a practical alternative for improving endometrial receptivity - A clinical retrospective study","volume":"24","author":"Frantz","year":"2020","journal-title":"JBRA Assist Reprod"},{"key":"R2-20250513","first-page":"508","article-title":"Infertility and sexual dysfunctions: A systematic literature review","volume":"58","author":"Starc","year":"2019","journal-title":"Acta Clin Croat"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s10815-021-02146-9","article-title":"A narrative review of platelet-rich plasma (PRP) in reproductive medicine","volume":"38","author":"Sharara","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"R4-20250513","doi-asserted-by":"crossref","first-page":"84","DOI":"10.5935\/1518-0557.20210046","article-title":"Effects of autologous platelet-rich plasma in women with repeated implantation failure undergoing assisted reproduction","volume":"26","author":"Bakhsh","year":"2022","journal-title":"JBRA Assist Reprod"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.3390\/medicina59091532","article-title":"Autologous platelet-rich plasma (PRP) efficacy on endometrial thickness and infertility: A single-centre experience from Romania","volume":"59","author":"Huniadi","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"R6-20250513","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4274\/tjod.galenos.2023.46588","article-title":"How autologous platelet-rich plasma affects pregnancy and birth outcomes in women with repeated embryo implantation failure: A prisma-compliant meta-analysis","volume":"20","author":"Soliman","year":"2023","journal-title":"Turk J Obstet Gynecol"},{"key":"R7-20250513","first-page":"1286","article-title":"Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization","volume":"8","author":"Chang","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"R8-20250513","first-page":"442","article-title":"Platelet-rich plasma as an effective alternative approach for improving endometrial receptivity \u2013A clinical retrospective study","volume":"24","author":"Frantz","year":"2020","journal-title":"JBRA Assist Reprod"},{"key":"R9-20250513","first-page":"443","article-title":"Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT","volume":"17","author":"Nazari","year":"2019","journal-title":"Int J Reprod Biomed"},{"key":"R10-20250513","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fendo.2019.00061","article-title":"Effect of autologous platelet-rich plasma treatment on refractory thin endometrium during the frozen embryo transfer cycle: A pilot study","volume":"10","author":"Kim","year":"2019","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_260_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:45:03Z","timestamp":1787773503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_260_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":10,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_260_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,21]]},"assertion":[{"value":"2025-01-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}