{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:30:39Z","timestamp":1788517839246,"version":"build-2803163510"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Chronic periodontitis is an infectious disease which is multifactorial in etiology. The red complex bacteria have an enzyme capable of hydrolyzing the synthetic trypsin substrate, N-benzoyl-DL-arginine-2-napthylamide (BANA). Tetracycline as a bacteriostatic agent is used in the treatment of periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate clinically and microbiologically the efficacy of tetracycline fibers in conjunction with scaling and root planning in chronic periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A Split mouth clinical and microbiological randomized control study was done to compare the clinical effects of subgingivally delivered antimicrobial bioabsorbable controlled release 2 mg tetracycline fibers as an adjunct to scaling and root planning on one side and comparing the other side treated only with scaling and root planning only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>Showed both scaling and root planning and the use of tetracycline an adjunct with scaling and root planning are equally effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It can be concluded that Scaling and root planing (SRP) with or without use of adjunct local drug delivery agent like tetracycline is effective in treating chronic periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_263_23","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T02:07:37Z","timestamp":1689127657000},"page":"S968-S970","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Microbiological and Clinical Evaluation of Efficacy of Locally Delivered Tetracycline in Conjunction with Scaling and Root Planning"],"prefix":"10.4103","volume":"15","author":[{"given":"Pragya","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Periodontology, Shree Bankey Bihari Dental College and Research Institute, Masuri, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parshad","family":"Mehta","sequence":"additional","affiliation":[{"name":"BDS, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devansh","family":"Manocha","sequence":"additional","affiliation":[{"name":"BDS, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandesh J.","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, A.C.P.M. Dental College, Dhule, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahmananda","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya D.","family":"Kosuri","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopaedics, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"R1-20240829","first-page":"4","article-title":"Effect of local drug delivery in chronic periodontitis patients:A meta-analysis","volume":"15","author":"Kalsi","year":"2011","journal-title":"J Indian Soc Periodontol"},{"key":"R2-20240829","first-page":"72","article-title":"Porphyromonas gingivalis, treponema denticola, and Tannerella forsythia:The _red complex_a prototype polybacterial pathogenic consortium in periodontitis","volume":"38","author":"Stanley","year":"2008","journal-title":"Periodontol 2000"},{"key":"R3-20240829","first-page":"224","volume":"24","author":"Andrade","year":"2010","journal-title":"The ability of the BANA Test to detect different levels of P.gingivalis, T.denticola and T.forsythia Braz Oral Res"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1034\/j.1600-051X.2002.291001.x","article-title":"Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters of periodontal syndrome","volume":"29","author":"Grisi","year":"2002","journal-title":"J Clin Periodontol"},{"key":"R6-20240829","first-page":"130","article-title":"Evaluation of commercially available biodegradable tetracycline fiber therapy fiber in chronic periodontitis","volume":"15","author":"Sachdeva","year":"2011","journal-title":"J Clin Periodontol"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1902\/jop.1982.53.10.604","article-title":"The effect of long term low dose tetracycline therapy on the subgingival microflora in refractory adult periodontitis","volume":"53","author":"Kornman","year":"1982","journal-title":"J Periodontol"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1902\/jop.2002.73.1.13","article-title":"Controlled local delivery of tetracycline with polymer strips in the treatment of periodontitis","volume":"73","author":"Friesen","year":"2002","journal-title":"J Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_263_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:30:23Z","timestamp":1786725023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_263_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":7,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_263_23","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2023-03-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}