{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:31:54Z","timestamp":1787070714472,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n \n \u201c\n Root canal treatment<\/jats:italic>\n (RCT)\u201d is essential in preserving natural dentition by eliminating infection within the root canal system. Irrigation solutions play a crucial role in achieving successful RCT outcomes by facilitating disinfection and debris removal.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n An\n in vitro<\/jats:italic>\n experimental design was employed to evaluate the irrigation solutions. Antimicrobial efficacy was assessed using agar diffusion assays against\n Enterococcus faecalis<\/jats:italic>\n and Candida albicans. Tissue dissolution ability was evaluated by measuring the weight loss of dentin specimens. Cytotoxicity was assessed using cell viability assays with human periodontal ligament fibroblasts.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n NaOCl demonstrated the highest antimicrobial efficacy, while EDTA exhibited superior tissue dissolution ability. CHX and QMix displayed lower cytotoxicity compared to NaOCl and EDTA.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The choice of irrigation solution in RCT should consider factors such as antimicrobial efficacy, tissue dissolution ability, and cytotoxicity. NaOCl remains effective but has high cytotoxicity, whereas CHX and QMix offer alternatives with lower cytotoxicity. EDTA is effective in tissue dissolution but should be used cautiously due to cytotoxic potential. Clinicians should weigh the benefits and limitations of each solution for optimal treatment outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_276_24","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T06:02:22Z","timestamp":1718258542000},"page":"S2740-S2742","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Analysis of Various Irrigation Solutions in Root Canal Treatment"],"prefix":"10.4103","volume":"16","author":[{"given":"Mubashir Baig","family":"Mirza","sequence":"first","affiliation":[{"name":"Department of Conservative Dental Science, College of Dentistry, Prince Sattam bin AbdulAziz University, AlKharj, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Vyas Dental College Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitharanjan","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte Deemed to be University, Derlakatte Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayantika","family":"Gupta","sequence":"additional","affiliation":[{"name":"BDS, Dental Surgeon, Smile Architects, Amritsar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinjal","family":"Padariya","sequence":"additional","affiliation":[{"name":"BDS, K.M. Shah Dental College and Hospital, Waghodia, Vadodara, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh","family":"Chohan","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alen","family":"Pius","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry & Endodontics, Malabar Dental College, Edappal, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cden.2009.12.001","article-title":"Irrigation in endodontics","volume":"54","author":"Haapasalo","year":"2010","journal-title":"Dent Clin North Am"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1365-2591.2008.01540.x","article-title":"The properties and applications of chlorhexidine in endodontics","volume":"42","author":"Mohammadi","year":"2009","journal-title":"Int Endod J"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1590\/0103-6440201302188","article-title":"Chlorhexidine in endodontics","volume":"24","author":"Gomes","year":"2013","journal-title":"Braz Dent J"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.joen.2005.09.014","article-title":"Root canal irrigants","volume":"32","author":"Zehnder","year":"2006","journal-title":"J Endod"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.joen.2012.04.003","article-title":"Antimicrobial substantivity over time of chlorhexidine and cetrimide","volume":"38","author":"Baca","year":"2012","journal-title":"J Endod"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.joen.2006.10.007","article-title":"Effect of smear layer on sealing ability of canal obturation: A systematic review and meta-analysis","volume":"33","author":"Shahravan","year":"2007","journal-title":"J Endod"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0099-2399(85)80197-7","article-title":"Cytotoxic effects of NaOCl on vital tissue","volume":"11","author":"Pashley","year":"1985","journal-title":"J Endod"},{"key":"R8-20240829","first-page":"125","article-title":"An in vitro comparison of the antibacterial efficacy of tri-antibiotic mixture, double and triple antibiotic pastes","volume":"9","author":"Zand","year":"2014","journal-title":"Iran Endod J"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.5005\/jp-journals-10024-2939","article-title":"Comparative study of antifungal efficacy of various endodontic irrigants with and without clotrimazole in extracted teeth inoculated with Candida albicans","volume":"21","author":"Srinivasan","year":"2020","journal-title":"J Contemp Dent Pract"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_276_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:35:18Z","timestamp":1787067318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_276_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,7]]},"references-count":9,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_276_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,7]]},"assertion":[{"value":"2024-03-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}